PEPTIDESTAT
Research onlyMetabolic healthSubcutaneousEvidence 3/5

Amylin

Also known as: IAPP, islet amyloid polypeptide

Amylin, co-secreted with insulin from pancreatic beta-cells, activates brainstem amylin receptors (calcitonin receptor paired with RAMPs) to promote satiation, slow gastric emptying, and suppress postprandial glucagon.

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Amylin
Drug class
Amylin receptor agonist (calcitonin peptide family hormone)
Primary targets
Amylin receptor AMY1 (CTR+RAMP1), Amylin receptor AMY2 (CTR+RAMP2), Amylin receptor AMY3 (CTR+RAMP3), Calcitonin receptor, Area postrema (brainstem)
Dose reference
No established dose for native amylin; it is an endogenous hormone, not a marketed consumer drug. Reference range applies only to the approved analog pramlintide (Symlin), dosed 15-120 mcg subcutaneously before meals per the FDA label (informational, not a recommendation).
Half-life
Native human amylin: approximately 13 minutes (short, rapidly degraded by insulin-degrading enzyme and renal clearance)
Developer / origin
Identified 1986-1987 by Per Westermark (Uppsala University) and Garth Cooper (University of Oxford)
Reference year
1987
Evidence score
3/5 - Mixed: strong physiology, analog-only human evidence
Evidence 3/5

Mixed: strong physiology, analog-only human evidence

Amylin's physiology (satiation, slowed gastric emptying, glucagon suppression) and RAMP-based receptor pharmacology are well established in primary literature, but human therapeutic evidence comes from engineered analogs such as pramlintide, not native amylin, which aggregates into cytotoxic islet amyloid and has a ~13-minute half-life.

Limited human pharmacology or small clinical evidence.

Evidence basis

  • Physiological Reviews and PMC mechanistic reviews document satiation, gastric emptying, and glucagon effects
  • IUPHAR classification and RAMP studies map amylin receptors as calcitonin receptor + RAMP1/2/3
  • FDA Symlin label establishes human evidence for the analog pramlintide, not native amylin
  • Nature and PMC sources document amylin aggregation and beta-cell cytotoxicity

How to read this entry

Dose references and half-life values are pulled from trial protocols, labels, reviews, or published summaries where available. They are context for research and comparison, not a personal dosing recommendation.

Status matters: approved drugs have regulated indications; investigational compounds are still being studied; research-only peptides do not have established human dosing, safety, or efficacy for consumer use.

Amylin guides

Read the matching guide or adjacent research pages for more context.

Amylin Peptide: IAPP Biology, Satiety Signaling and Drug DevelopmentAmylin is an endogenous beta-cell hormone behind satiety and glucose control, but native amylin aggregates and is a research target rather than a consumer drug.Pramlintide: Amylin Analog Evidence, Weight Loss and Safety LimitsPramlintide is the approved amylin analog behind Symlin, but its weight-loss story is narrower than newer obesity-amylin marketing suggests.Peptides for Weight Loss: GLP-1s, Tirzepatide, Retatrutide and What WorksA broad guide to weight-loss peptides, from approved GLP-1 and dual-incretin medicines to investigational retatrutide, cagrilintide and other research compounds.Cagrilintide: Amylin Evidence, CagriSema Results and SafetyCagrilintide is an investigational amylin analog. The strongest interest is CagriSema, Novo Nordisk's cagrilintide plus semaglutide combination.

Peptide calculators

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Peptide reconstitution calculatorCalculate concentration, draw volume and syringe units from vial strength and BAC water.Open toolPeptide accumulation calculatorModel repeated dosing schedules with half-life, interval, peak and trough estimates.Open toolPeptide unit converterConvert mg, mcg, optional IU and syringe units from one reconstituted vial setup.Open toolPeptide chemistry calculatorAnalyze sequence length, molecular weight, composition, charge, hydropathy and notation.Open tool

Compare with related peptides

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Glucagon

GlucaGen, Baqsimi, Gvoke

5/5
Metabolic healthApproved

Glucagon binds the hepatic glucagon receptor (GCGR), raising cyclic AMP to stimulate glycogenolysis and gluconeogenesis, which increases blood glucose as the body's main counter-regulatory hormone opposing insulin.

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Research & educational purposes only

The information on PeptideStat is for educational and research purposes only and is not medical advice. Many peptides discussed are research compounds not approved for human use. Always consult a qualified healthcare professional before making any health decisions. Articles may contain affiliate links — we may earn a commission at no extra cost to you.