PEPTIDESTAT
ApprovedReproductive & hormoneSubcutaneousEvidence 4/5

Buserelin

Also known as: Suprefact

Buserelin is a GnRH receptor superagonist that initially stimulates and then, with continuous non-pulsatile exposure, desensitizes pituitary gonadotrophs to suppress LH, FSH and downstream testosterone or estradiol production.

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Buserelin
Drug class
GnRH agonist (LHRH analogue)
Primary targets
GnRH/LHRH receptor, Pituitary gonadotrophs, LH, FSH
Dose reference
Label/trial reference figures, not recommendations: advanced prostate cancer 500 mcg SC every 8 hours for 7 days, then 200 mcg SC daily or 400 mcg intranasally three times daily; endometriosis 400 mcg intranasally three times daily for up to ~6 months.
Half-life
Short elimination half-life, reported around 72-80 minutes (about 1-2 hours) regardless of route.
Developer / origin
Hoechst AG (Frankfurt, Germany); rights now held by Sanofi
Reference year
1984
Evidence score
4/5 - Approved GnRH agonist with label and trial support

Approved uses

  • Hormone-dependent advanced (metastatic) prostate cancer (e.g. Health Canada Suprefact label)
  • Endometriosis
  • Pituitary down-regulation in assisted reproduction/IVF (protocol use)
Evidence 4/5

Approved GnRH agonist with label and trial support

Buserelin is an approved GnRH agonist (Suprefact) in Canada and parts of Europe for hormone-dependent advanced prostate cancer and endometriosis, with a substantial randomized/comparative trial record for IVF down-regulation; it is not FDA-approved in the US.

Investigational compound with human randomized or phase 2/3 evidence.

Evidence basis

  • Health Canada Suprefact product monograph documents approved prostate cancer and endometriosis indications, dosing and safety
  • Multiple PubMed-indexed randomized and comparative trials evaluate buserelin for IVF down-regulation and GnRH-agonist ovulation triggering
  • Pharmacovigilance and pharmacology literature characterize class mechanism, ~72-80 min half-life and adverse-event profile

How to read this entry

Dose references and half-life values are pulled from trial protocols, labels, reviews, or published summaries where available. They are context for research and comparison, not a personal dosing recommendation.

Status matters: approved drugs have regulated indications; investigational compounds are still being studied; research-only peptides do not have established human dosing, safety, or efficacy for consumer use.

Buserelin guides

Read the matching guide or adjacent research pages for more context.

Buserelin Peptide: Suprefact, GnRH Agonist Uses and Safety LimitsBuserelin is an approved GnRH agonist peptide (Suprefact) used for prostate cancer, endometriosis and IVF down-regulation, with strong hormone-suppression evidence and important safety limits.Atosiban Peptide: Tractocile, Oxytocin Antagonist Tocolytic for Preterm LaborAtosiban is an EU-approved oxytocin and vasopressin receptor antagonist peptide used intravenously as a short-term tocolytic to delay preterm labor.Carbetocin Peptide: Long-Acting Oxytocin Analog for Postpartum HemorrhageCarbetocin is an approved long-acting oxytocin analog peptide used to prevent postpartum hemorrhage, with a heat-stable formulation and label-backed evidence.Cetrorelix Peptide: Cetrotide, GnRH Antagonist Uses and SafetyCetrorelix is an FDA-approved GnRH antagonist peptide used in IVF to block premature LH surges without the early flare of GnRH agonists.

Peptide calculators

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Compare with related peptides

Stay inside the same research category and compare mechanism, status and evidence quality.

Triptorelin

Trelstar, Decapeptyl

5/5
Reproductive & hormoneApproved

Triptorelin is a potent GnRH-receptor agonist that first transiently stimulates LH and FSH release, then, with continuous exposure, downregulates and desensitizes pituitary GnRH receptors to suppress gonadotropins and sex steroids.

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Goserelin

Zoladex

5/5
Reproductive & hormoneApproved

Goserelin is a synthetic decapeptide GnRH agonist that first stimulates and then, with continuous depot exposure, downregulates pituitary GnRH receptors to suppress LH, FSH and downstream sex steroids toward castrate or postmenopausal levels.

DetailsGuide

Nafarelin

Synarel

4/5
Reproductive & hormoneApproved

Nafarelin is a potent GnRH receptor agonist that initially stimulates pituitary LH and FSH release but with continued dosing downregulates the receptor, suppressing gonadotropins and sex steroid production.

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Histrelin

Supprelin LA, Vantas

4/5
Reproductive & hormoneApproved

Histrelin is a GnRH receptor agonist that initially stimulates and then, through continuous implant delivery, downregulates pituitary GnRH receptors to suppress LH, FSH and sex steroid production.

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Research & educational purposes only

The information on PeptideStat is for educational and research purposes only and is not medical advice. Many peptides discussed are research compounds not approved for human use. Always consult a qualified healthcare professional before making any health decisions. Articles may contain affiliate links — we may earn a commission at no extra cost to you.