PEPTIDESTAT
ApprovedClinical / approved drugIntramuscularEvidence 4/5

Carbetocin

Also known as: Duratocin, Pabal, Lonactene

Carbetocin is a long-acting synthetic oxytocin analog that acts as an agonist at peripheral oxytocin receptors in the uterine myometrium, producing sustained contractions that reduce postpartum bleeding.

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Carbetocin
Drug class
Long-acting oxytocin analog (uterotonic)
Primary targets
Oxytocin receptor (myometrium)
Dose reference
Label/trial reference: single 100 microgram dose (IV over ~1 min after cesarean per Duratocin label; IM after vaginal birth in the CHAMPION trial) - not a recommendation
Half-life
Approximately 85-100 minutes (vs ~3.5 minutes for oxytocin)
Developer / origin
Ferring Pharmaceuticals (originally synthesized at the Czechoslovak Institute of Organic Chemistry and Biochemistry; heat-stable version developed with MSD for Mothers and WHO)
Reference year
1997
Evidence score
4/5 - Strong, label-backed clinical evidence

Approved uses

  • Prevention of uterine atony and postpartum hemorrhage following cesarean section
  • Prevention of postpartum hemorrhage following vaginal delivery (heat-stable formulation)
Evidence 4/5

Strong, label-backed clinical evidence

Carbetocin is approved in many countries for postpartum hemorrhage prevention and is supported by the large WHO-led CHAMPION randomized trial, a Cochrane network meta-analysis, and WHO essential-medicines listing for the heat-stable formulation; evidence shows non-inferiority to oxytocin rather than clear superiority, and it is not FDA approved in the US.

Investigational compound with human randomized or phase 2/3 evidence.

Evidence basis

  • CHAMPION trial (NEJM 2018): ~29,600 women, heat-stable carbetocin non-inferior to oxytocin for >=1000 mL blood loss after vaginal birth, but did not meet non-inferiority for the >=500 mL outcome
  • 2018 Cochrane network meta-analysis: carbetocin may reduce need for additional uterotonics versus oxytocin, especially after cesarean, with cautious GRADE certainty
  • Ferring Duratocin product monograph confirms approved indication, single 100 microgram dose, and oxytocin-receptor mechanism
  • 2021 systematic review/meta-analysis: side-effect burden broadly comparable to oxytocin
  • Not FDA approved in the US; intranasal carbetocin (LV-101) program for Prader-Willi syndrome did not gain FDA approval

How to read this entry

Dose references and half-life values are pulled from trial protocols, labels, reviews, or published summaries where available. They are context for research and comparison, not a personal dosing recommendation.

Status matters: approved drugs have regulated indications; investigational compounds are still being studied; research-only peptides do not have established human dosing, safety, or efficacy for consumer use.

Carbetocin guides

Read the matching guide or adjacent research pages for more context.

Carbetocin Peptide: Long-Acting Oxytocin Analog for Postpartum HemorrhageCarbetocin is an approved long-acting oxytocin analog peptide used to prevent postpartum hemorrhage, with a heat-stable formulation and label-backed evidence.Abaloparatide Peptide: Tymlos, PTHrP Analog Uses and Safety LimitsAbaloparatide is an FDA-approved PTHrP(1-34) analog peptide that builds bone in high-risk osteoporosis, backed by the ACTIVE and ATOM trials with clear duration and safety limits.Atosiban Peptide: Tractocile, Oxytocin Antagonist Tocolytic for Preterm LaborAtosiban is an EU-approved oxytocin and vasopressin receptor antagonist peptide used intravenously as a short-term tocolytic to delay preterm labor.Bivalirudin Peptide: Angiomax Direct Thrombin Inhibitor GuideBivalirudin is an FDA-approved, hirudin-derived bivalent direct thrombin inhibitor used as a short-acting intravenous anticoagulant during percutaneous coronary intervention.

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