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Research onlyGrowth hormoneSubcutaneousEvidence 2/5

MGF (Mechano Growth Factor)

Also known as: IGF-1Ec

MGF is the IGF-1Ec splice variant whose distinct C-terminal E-domain peptide, induced by mechanical loading or damage, is proposed to activate satellite cells ahead of mature IGF-1 signaling.

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MGF (Mechano Growth Factor)
Drug class
IGF-1 splice variant / E-domain peptide
Primary targets
Satellite (muscle stem) cells, Myoblasts
Dose reference
No established or approved human dose; research-only
Half-life
Very short; minutes for the native E-peptide
Developer / origin
Goldspink et al. (University College London)
Reference year
2002
Evidence score
2/5 - Preclinical and contested
Evidence 2/5

Preclinical and contested

MGF (IGF-1Ec) is a genuine mechano-responsive IGF-1 splice variant linked to muscle repair, but evidence is largely cell/animal work, some conflicting, with no approved human therapeutic.

Mostly animal, ex vivo, cell, or indirect evidence.

Evidence basis

  • Load-induced IGF-1Ec splicing associated with satellite-cell activation
  • Proposed distinct E-domain role in myoblast proliferation
  • Independent E-peptide activity is contested in the literature
  • No controlled human hypertrophy or recovery trials

How to read this entry

Dose references and half-life values are pulled from trial protocols, labels, reviews, or published summaries where available. They are context for research and comparison, not a personal dosing recommendation.

Status matters: approved drugs have regulated indications; investigational compounds are still being studied; research-only peptides do not have established human dosing, safety, or efficacy for consumer use.

MGF (Mechano Growth Factor) guides

Read the matching guide or adjacent research pages for more context.

MGF Peptide: IGF-1Ec Biology, Muscle Repair Evidence and LimitsMGF is the IGF-1Ec splice variant linked to mechanical loading and muscle repair, but the evidence is largely cell and animal data, and no human therapeutic is approved.PEG-MGF Peptide: Muscle Growth Claims, Evidence and Safety LimitsPEG-MGF is marketed for muscle growth and repair, but the evidence is mostly mechanistic, cell, animal and doping-detection literature rather than human outcome trials.Sermorelin: What the GHRH Analog Does — and What It Doesn'tSermorelin is a GHRH (growth-hormone-releasing hormone) analog — not a GLP-1, despite being searched alongside them. What it does to growth hormone, and where it stands legally.GHRP-2 Peptide: Pralmorelin, GH Secretagogue Science and SafetyGHRP-2, or pralmorelin, is a ghrelin-receptor growth hormone secretagogue approved in Japan only as a GH-deficiency diagnostic, not as a consumer therapeutic.

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The information on PeptideStat is for educational and research purposes only and is not medical advice. Many peptides discussed are research compounds not approved for human use. Always consult a qualified healthcare professional before making any health decisions. Articles may contain affiliate links — we may earn a commission at no extra cost to you.