DRUG
Vasopressin and Epinephrine Versus Epinephrine Alone in Cardiac Arrest
Status
Completed
Phase
Phase 4
Enrollment
2,416
Locations
1
Results
Not posted
Publications
1
Study summary
What the protocol is testing.
Recent studies have suggested that arginine-vasopressin could be more effective in the treatment of cardiac arrests. The last published study did not outline obvious improvements in the prognosis of all cardiac arrests but pointed out a possible increased survival rate when arginine-vasopressin is associated with epinephrine. The aim of this study is to compare the efficacy of two successive injections of epinephrine (1 mg) with two successive injections of epinephrine associated with arginine-vasopressin (40 UI) in out-of-hospital cardiac arrests occurring in adult patients. The primary endpoint is the survival rate at hospital admission. The inclusion period lasts 18 months and 2416 patients are planned to be enrolled.
Interventions
Treatment arms and agents.
DRUG
arginine-vasopressin (40 UI/2 mL)
Timeline
From registration to results.
First posted
Aug 9, 2005
Study start
May 2, 2004
Primary completion
Oct 1, 2007
Study completion
Oct 1, 2007
Results posted
Not reported
Registry updated
Jun 11, 2026
Outcomes
What the study measures.
Primary outcomes
Survival at hospital admission
Secondary outcomes
ROSC (Return of spontaneous circulation) Survival at : H24, Day 28, hospital discharge and one year Neurological status at H24 and hospital discharge.
Eligibility
Who can take part.
- Minimum age
- 18 Years
- Maximum age
- 85 Years
- Sex
- ALL
- Healthy volunteers
- No
Inclusion Criteria: * Out-of-hospital medical cardiac arrest in adult patients. Exclusion Criteria: * Traumatic cardiac arrest * Pregnancy * Patients younger than 18 years old or older than 85 years old
Study locations
1 registered sites.
France. Showing up to 24 locations stored in the fast local snapshot.
Centre Hospitalier Lyon Sud
Pierre-Bénite, France
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Related PeptideStat pages
Put the record in context.
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