Healthy Normal Single Ascending Dose and Crohn's Patient Multiple Ascending Dose

Inclusion Criteria: * Healthy adult male and/or females, 18 to 50 years of age * Body mass index (BMI)18-30. Chrons Inclusion * Adult male and/or females, 18 to 60 years of age (inclusive). * Body mass index (BMI) ≥ 18 and ≤ 30 (kg/m2). * Crohn's Disease Activity Index (CDAI) score \< 150. * In a stable state of Crohn's disease as per the Investigator's opinion. * Free of steroid treatment (therapy targeted for the GI tract only) within the 3 months prior to Day 1. Exclusion Criteria: * History or presence of dysplasia, cancer, chronic hepatitis, HIV, tuberculosis (TB), or histoplasmosis. * Fistula within the 3 months prior to dosing. 3. Ostomy (having ostomy now or at any time in the past). 4. Any surgery for the treatment of inflammatory bowel disease (IBD) within the 3 months prior to Day 1. 5. Short Bowel Syndrome (SBS). 6. Any other condition, chronic disease, or prior therapy, which in the opinion of the Investigator/Investigator's designee would put the patient at undue risk or would make the patient unsuitable for the study.