PROCEDURE
Forearm vascular study
Forearm blood flow measured by venous occlusion plethysmography during interarterial infusion of vasodilators (Ach). Venous blood sampling via cannula in antecubital fossa.
The Effect of Ischaemic-Reperfusion in Man - A Bradykinin Dependent Pathway
Status
Completed
Phase
Not applicable
Enrollment
12
Locations
1
Results
Not posted
Publications
1
Study summary
What the protocol is testing.
Heart attacks are usually caused by a blood clot blocking an artery supplying blood to the heart. Current treatments are designed to relieve this blockage as quickly as possible to minimize damage to the heart muscle. However in restoring the supply of blood local damage known as "ischaemia-reperfusion injury" may occur. The aim of this study is to assess how clot forming and clot dissolving pathways are affected during this process, and examine the role of a natural inflammatory hormone, bradykinin. This will help the investigators to understand the mechanism by which ischaemia-reperfusion injury may occur and to devise new treatments for heart attacks.
Interventions
Treatment arms and agents.
DRUG
bradykinin receptor antagonist (HOE-140)
Systemic infusion of bradykinin receptor antagonist (HOE-140).
DRUG
Placebo (saline)
Systemic infusion of placebo (saline).
Timeline
From registration to results.
First posted
Aug 25, 2009
Study start
Aug 2009
Primary completion
Oct 2010
Study completion
Oct 2010
Results posted
Not reported
Registry updated
Oct 25, 2010
Outcomes
What the study measures.
Primary outcomes
Change in forearm blood flow in response to vasodilators (ACh) and ischaemia reperfusion
Time frame · 20 fixed timepoints during each study visit (3hrs)
Secondary outcomes
Change in platelet-monocyte-binding after ischaemia reperfusion
Time frame · 4 fixed timepoints during each study visit (3hrs)
Eligibility
Who can take part.
- Minimum age
- 18 Years
- Maximum age
- 65 Years
- Sex
- MALE
- Healthy volunteers
- Yes
Inclusion Criteria: * healthy males between 18-65 years of ages * non-smokers Exclusion Criteria: * any concurrent illness or chronic medical condition * concurrent use of vasoactive medication * smoking history
Study locations
1 registered sites.
United Kingdom. Showing up to 24 locations stored in the fast local snapshot.
University of Edinburgh, 49 Little France Crescent
Edinburgh, United Kingdom
Publications
Results and literature.
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