DRUG
Atosiban
Bolus atosiban 6.75mg + infusion atosiban 18mg/u during 3 hours. once administered starting 1 hour before embryotransfer.
Oxytocin Antagonist in Patients With Repeated Failure of Implantation
Status
Completed
Phase
Phase 4
Enrollment
138
Locations
1
Results
Not posted
Publications
1
Study summary
What the protocol is testing.
In this study the investigators compare the usual way of embryo transfer (without medication) with an embryo transfer while administering oxytocine antagonist. This to improve implantation and increase the pregnancy rate.
Interventions
Treatment arms and agents.
DRUG
placebo
Timeline
From registration to results.
First posted
Aug 28, 2012
Study start
Feb 2012
Primary completion
Feb 2015
Study completion
Feb 2015
Results posted
Not reported
Registry updated
Feb 2, 2021
Outcomes
What the study measures.
Primary outcomes
implantation rate
Time frame · 16 days from eggretrieval
the number of patients that show a positive serum blood pregnancy test
Secondary outcomes
pregnancy rate
Time frame · 12 weeks
The number of patients with an ongoing first trimester pregnancy
Eligibility
Who can take part.
- Minimum age
- 18 Years
- Maximum age
- 38 Years
- Sex
- FEMALE
- Healthy volunteers
- No
Inclusion Criteria: * IVF/ ICSI patients below 38 years * 2e to 6e IVF-cycle Exclusion Criteria: * patients with endocrinological diseases or problems
Study locations
1 registered sites.
Belgium. Showing up to 24 locations stored in the fast local snapshot.
AZ Jan Palfijn
Ghent, Oost-vlaanderen, Belgium
Publications
Results and literature.
Related trials
More studies on Atosiban.
NCT IDStudyPhase / statusEnrollmentUpdated
Atosiban in Women With Previous Implantation Failure and Abnormal Uterine Contractions
Northwest Women's and Children's Hospital, Xi'an, Shaanxi · Infertility
Not applicable
Recruiting
792
2025-12
The Effect of Oral Oxytocin and Atosiban on Top-down Attention ( OTAtosiban )
University of Electronic Science and Technology of China · Healthy Adult Male
Early Phase 1
Recruiting
250
2025-09
The Effect of Oral Oxytocin and Atosiban on Social Attention
University of Electronic Science and Technology of China · Healhty
Early Phase 1
Recruiting
250
2025-07
Perioperative Use of Atosiban for Ultrasound-indicated Cerclage to Reduce Spontaneous Preterm Birth(sPTB)
Children's Hospital of Chongqing Medical University · Cervical Cerclage · Premature Birth
Not applicable
Completed
334
2025-05
Atosiban Versus Placebo in the Treatment of Late Threatened Pre-term Birth
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Preterm Birth
Phase 4
Completed
760
2024-07
In Utero Repair of Myelomeningocele: Atosiban Versus Terbutaline
University of Sao Paulo General Hospital · Myelomeningocele · Terbutaline Adverse Reaction
Not applicable
Completed
25
2022-06
The Effect of Selective Oxytocin Receptor Inhibitors on Endometriosis-related Pain
Radboud University Medical Center · Endometriosis
Phase 2
Unknown
10
2022-05
Role of Atosiban in Recurrent Implantation Failure
Al Baraka Fertility Hospital · Recurrent Implantation Failure
Not applicable
Unknown
150
2021-09
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