Study of MEDI0382 in Combination With Dapagliflozin and Metformin in Overweight/Obese Participants With Type 2 Diabetes

Inclusion Criteria: 1. Male and female participants aged \>= 18 years at screening. 2. Provision of signed and dated informed consent form (ICF) prior to any study specific procedures. 3. Body mass index between 25 kg/m\^2 and 40 kg/m\^2 (inclusive) at screening. 4. Hemoglobin A1c range between 7.0% and 10.0% (inclusive) at the time of screening. 5. Diagnosed with T2DM and treated with of metformin monotherapy (MTD \> 1 g) at least 8 weeks prior to screening or treated with stable, oral doses of dapagliflozin 10 mg and metformin (MTD \> 1 g) for at least 3 months prior screening. 6. Participants prescribed oral dual therapy with sulphonylurea, glitinide, or dipeptidyl peptidase-4 inhibitor (in addition to metformin) may be eligible to enter the study following a washout period of these medications totaling at least 28 days before initial screening evaluations have been completed. 7. Participants treated with stable doses of metformin (MTD \> 1 g) with canagliflozin (maximum dose of 300 mg/day), or metformin (MTD \> 1 g) with empaglifozin (maximum dose of 25mg/day) for at least 3 months prior to screening may be eligible to enter the study after switching to dapagliflozin. 8. Female participants of childbearing potential must have a negative pregnancy test at screening and randomization and must not be lactating. 9. Females of childbearing potential who are sexually active with a nonsterilized male partner must use at least one highly effective method of contraception from screening and must agree to continue using such precautions through to the end of the study. It is strongly recommended for the male partner of a female participant to also use male condom plus spermicide throughout this period. Cessation of contraception after this point should be discussed with a responsible physician. Periodic abstinence, the rhythm method, and the withdrawal method are not acceptable methods of contraception. Exclusion Criteria: 1. History of, or any existing condition that in the opinion of the investigator would interfere with evaluation of the investigational product, put the participant at risk, influence the participant's ability to participate, or affect the interpretation of the results of the study and/or any participant unable or unwilling to follow study procedures. 2. Any participant who has received another investigational product not included in the protocol as part of a clinical trial or a glucagon-like peptide-1 (GLP-1) analogue or sodium-glucose cotransporter-2 (SGLT2)-containing preparation (excluding dapagliflozin, canagliflozin, empagliflozin) within the last 30 days or 5 half-lives of the drug (whichever is longest) at the time of screening. 3. Any participant who has received any of the following medications prior to the start of the screening period (Visit 1) or prior to the study start period (Visit 4): * Concurrent use of any medicinal products, or herbal or over-the-counter (OTC) preparations licensed for control of body weight or appetite at the time of screening (Visit 1) * Concurrent or previous use of drugs approved for weight loss (eg, orlistat, bupropion-naltrexone, phentermine-topiramate, phentermine, lorcaserin) within the last 30 days or 5 half-lives of the drug (whichever is longest) at the time of screening (Visit 1) * Concurrent use of aspirin (acetylsalicylic acid) at a dose greater than 150 mg once daily and within the last 72 hours prior to the start of the study (Visit 4) * Concurrent use of paracetamol (acetaminophen) or paracetamol-containing preparations at a total daily dose of greater than 3000 mg and within the last 72 hours prior to the start of the study (Visit 4) * Concurrent use of ascorbic acid (vitamin C) supplements at a total daily dose greater than 1000 mg and within the last 72 hours prior to the start of the study (Visit 4) * Concurrent use of opiates, domperidone, metoclopramide, or other drugs known to alter gastric emptying and within the last 72 hours prior to the start of the study (Visit 4) 4. Concurrent participation in another study of any kind and repeat randomization in this study is prohibited. 5. Severe allergy/hypersensitivity to any of the proposed study treatments or excipients. 6. Diagnosis of type 1 diabetes mellitus, maturity-onset diabetes of the young, or latent autoimmune diabetes of adulthood or presence of anti-glutamic acid decarboxylase, anti-islet cell, or anti-insulin antibodies. 7. Symptoms of acutely decompensate blood glucose control (eg, thirst, polyuria, weight loss) at screening or randomization, a history of diabetes ketoacidosis (DKA), or hyperosmolar nonketotic coma or treatment with daily subcutaneous insulin within 90 days prior to screening. 8. Fasting hyperglycemia (\> 250 mg/dL/ \> 13.9 mmol/L) prior to randomization. 9. C-peptide level \< lower limit of normal (LLN). 10. History of acute or chronic pancreatitis or pancreatectomy. 11. Hypertriglyceridemia (\> 400 mg/dL) at screening. 12. Significant inflammatory bowel disease, gastroparesis, or other severe disease or surgery affecting the upper gastrointestinal (GI) tract (including weight-reducing surgery and procedures) which may affect gastric emptying or could affect the interpretation of safety and tolerability data. 13. Significant hepatic disease (except for nonalcoholic steatohepatitis or nonalcoholic fatty liver disease without portal hypertension or cirrhosis) and/or participants with any of the following results at screening: * Aspartate transaminase (AST) \>= 3 × upper limit of normal (ULN) * Alanine transaminase (ALT) \>= 3 × ULN * Total bilirubin (TBL) \>= 2 × ULN 14. Impaired renal function defined as estimated glomerular filtration rate (eGFR) \<= 60 mL/minute/1.73m\^2 at screening (eGFR according to Modification of Diet in Renal Disease \[MDRD\] using the isotope dilution mass spectrometry-traceable MDRD Study Equation (SI units). 15. Use of loop diuretics within 1 month prior to screening. 16. Poorly controlled hypertension as defined below: * Systolic blood pressure (BP) \> 160 mm Hg * Diastolic BP or \>= 100 mm Hg After 10 minutes of supine rest and confirmed by repeated measurement at screening (Visit 1 for all participants). 17. Unstable angina pectoris, myocardial infarction, transient ischemic attack, or stroke within 3 months prior to screening, or participants who have undergone percutaneous coronary intervention or a coronary artery bypass graft within the past 6 months or who are due to undergo these procedures at the time of screening. 18. Severe congestive heart failure (New York Heart Association Class III and IV) 19. Basal calcitonin level \> 50 ng/L at screening or history/family history of medullary thyroid carcinoma or multiple endocrine neoplasia. 20. Hemoglobinopathy, hemolytic anemia, or chronic anemia (hemoglobin concentration \< 11.5 g/dL \[115 g/L\] for males and \< 10.5 g/dL \[105 g/L\] for females) at screening or any other condition known to interfere with interpretation of HbA1c measurement. 21. History of neoplastic disease within 5 years prior to screening, except for adequately treated basal cell skin cancer, squamous cell skin cancer, or in situ cervical cancer. 22. Any positive results for serum hepatitis B surface antigen, hepatitis C antibody, and human immunodeficiency virus antibody. 23. Recent viral infection or illness requiring the use of antibiotics in the month prior to screening (Visit 1) for participants on dual therapy or prior to run-in period (Visit 2) for participants on monotherapy. 24. History of recurrent (at least 2) urinary tract and/or genital tract infections (including mycotic infections such as thrush) within 6 months prior to screening. 25. Substance dependence likely to impact participant safety or compliance with study procedures. 26. Involvement of any AstraZeneca, MedImmune, contract research organization, or study site employees and their close relatives.