L-NMMA on GLP-2 Mediated Intestinal Lipoprotein Release

Inclusion Criteria: * Men and women, aged 18 to 60 years * Body mass index 20 kg/m2 to 30 kg/m2 * Hemoglobin above 130g/L. * Normal glucose tolerance in response to a 75g, 2-hr oral glucose tolerance test Exclusion Criteria: * Subject has a history of hepatitis/hepatic disease that has been active within the previous two years. * Any significant active (over the past 12 months) disease of the gastrointestinal, pulmonary, neurological, renal (creatinine \> 1.5 mg/dL), genitourinary, hematological systems, or has severe uncontrolled treated or untreated hypertension (sitting diastolic blood pressure \> 100 or systolic \> 180) or proliferative retinopathy * History of diabetes or oral glucose tolerance indicative of diabetes or impaired glucose tolerance. * Any history of a myocardial infarction or clinically significant, active, cardiovascular history including a history of arrhythmia's or conduction delays on electrocardiogram, unstable angina, or decompensated heart failure. * Any laboratory values: aspartate transaminase \> 2x upper limit of normal; alanine aminotransferase \> 2x upper limit of normal; thyroid-stimulating hormone \> 6 miliunit/l * Current addiction to alcohol or substances of abuse as determined by the investigator. * Mental incapacity, unwillingness or language barrier precluding adequate understanding or cooperation * Taking any prescription or non-prescription medications at the time of the study * Having donated blood three months prior to and three months post study procedures * A pregnancy test will be performed 1 to 3 days prior to each study in all female research participants. Those who test positive for pregnancy will be excluded.