Follitropin Delta in Long GnRH Agonist and GnRH Antagonist Protocols (BEYOND)

Number of Oocytes Retrieved

Time frame · On day of oocyte retrieval (up to 22 days after start of stimulation)

The number of oocytes retrieved was recorded at the oocyte retrieval visit.

Proportion of Subjects With Cycle Cancellation Due to Poor Ovarian Response or Excessive Ovarian Response

Time frame · At end-of-stimulation (up to 20 days)

For each participant, the reason for cycle cancellation was recorded

Proportion of Subjects With Blastocyst Transfer Cancellation After Oocyte Retrieval Due to (Risk of) Ovarian Hyperstimulation Syndrome (OHSS)

Time frame · At end of transfer (up to 4 weeks)

For each participant, the reason for blastocyst transfer cancellation was recorded.

Number of Follicles

Time frame · On stimulation day 6 and at end-of-stimulation (up to 20 days)

The total number of follicles and the number of follicles per size category will be reported

Proportion of Subjects With <4, 4-7, 8-14, 15-19 and ≥20 Oocytes Retrieved

Time frame · On day of oocyte retrieval (up to 22 days after start of stimulation)

Grouped according to number of oocytes

Number of Metaphase II Oocytes

Time frame · On day of oocyte retrieval (up to 22 days after start of stimulation)

Only applicable for those inseminated using ICSI

Fertilization Rate

Time frame · On day 1 after oocyte retrieval (up to 23 days after start of stimulation)

Measured by the number of pronuclei. Fertilized oocytes with 2 pronuclei were regarded as correctly fertilized

Number of Embryos

Time frame · On day 3 after oocyte retrieval (up to 25 days after start of stimulation)

The number of embryos (total and good-quality) was reported. Embryo quality is determined by combined assessment of cleavage stage (number of blastomeres/compaction status) and embryo morphology parameters

Number of Blastocysts

Time frame · On day 5 after oocyte retrieval (up to 27 days after start of stimulation)

The number of blastocysts (total and good-quality) was reported. Blastocyst quality is assessed by blastocyst expansion and hatching status, blastocyst inner cell mass grading, and trophectoderm grading. The scoring is based on the classification system by Gardner and Schoolcraft, with additional categories for inner cell mass (degenerative or no inner cell mass) and trophectoderm (degenerative or very large cells)

Circulating Concentrations of Follicle-stimulating Hormone (FSH)

Time frame · On stimulation day 6, at end-of-stimulation (up to 20 days after start of stimulation) and at oocyte retrieval (up to 22 days after start of stimulation)

Blood samples for analysis of circulating concentrations of FSH were drawn.

Circulating Concentrations of Luteinizing Hormone (LH)

Time frame · On stimulation day 6, at end-of-stimulation (up to 20 days after start of stimulation) and at oocyte retrieval (up to 22 days after start of stimulation)

Blood samples for analysis of circulating concentrations of LH were drawn