A Study in Adults With Hereditary Angioedema (HAE) Who Currently Receive Icatibant at Home

Number of Participants Treated with Icatibant in the Homecare Setting who Were Receiving Prophylaxis Treatment at Index

Time frame · Up to 12 months from Index (day of the first homecare telephonic consultation/visit)

Number of Participants Treated with Icatibant in the Homecare Setting in Each Prophylactic Treatment Type

Time frame · Up to 12 months from Index (day of the first homecare telephonic consultation/visit)

Number of Participants Categorized by Their Demographic Characteristics

Time frame · Baseline Period [3 months prior to Index (day of the first homecare telephonic consultation/visit)]

Demographic characteristics will include age at index (categories: 18-29, 30-39, 40-49, 50-59, 60+ years), sex (male, female, non-binary), and ethnic group.

Number of Participants Categorized by Their Clinical Characteristics

Time frame · At Index (day of the first homecare telephonic consultation/visit)

Clinical characteristics will include patient reported HAE type (Type I or Type II), categories of duration (participant's self-administration of icatibant at home and time since HAE diagnosis) at index, comorbidities, prior HAE related concomitant medication details, categories of details of deaths during the study observation period.

Rate of New HAE Attacks

Time frame · Up to 12 months from Index (day of the first homecare telephonic consultation/visit)

Rate of new HAE attacks and rate of new HAE attacks that required treatment in homecare setting will be recorded as number of HAE attacks per participant per month. Data would be reported for pre-defined time-period categories as follows: between index to month 3, between month 3 to 6, month 6 to 9 and month 9 to 12.

Frequency of Visits to Accident and Emergency Services Related to an HAE Attack

Time frame · Up to 12 months from Index (day of the first homecare telephonic consultation/visit)

Frequency of visits to Accident and Emergency Services related to an HAE attack will be defined as number of visits to Accidents and Emergency Services during pre-defined time period. Data would be reported for pre-defined time-period categories as follows: between index to month 3, between month 3 to 6, month 6 to 9 and month 9 to 12.

Time from the Start of Each HAE Attack to Administration of Icatibant in the Homecare Setting

Time frame · Up to 12 months from Index (day of the first homecare telephonic consultation/visit)

The summary data for time (in hours) from the start of each HAE attack to administration of icatibant in the homecare setting will be reported.

Frequency of Icatibant Administration Following Start of Each HAE Attack

Time frame · Up to 12 months from Index (day of the first homecare telephonic consultation/visit)

The summary data for number of icatibant administration following start of each HAE attack during the predefined time period will be reported.

Number of Participants by Treatment Patterns

Time frame · Up to 12 months from Index (day of the first homecare telephonic consultation/visit)

Treatment patterns will include assessment of number of participants by treatment dose received for HAE attack and average dose per participant received post-index.

Number of Participants by Treatment Management Patterns

Time frame · Up to 12 months from Index (day of the first homecare telephonic consultation/visit)

Treatment management patterns will include assessment of number of participants by discontinuations of icatibant treatment and reasons for discontinuation (this would be assessed for participants who received prophylaxis treatment during the study), number of face-to-face and telephone-based homecare consultations.

EQ-5D-5L Score

Time frame · Up to 12 months from Index (day of the first homecare telephonic consultation/visit)

The EQ-5D-5L questionnaire will be used to record impact of HAE on participant's quality-of-life (QoL). The EQ-5D-5L is a descriptive system of Health-Related Quality-of-Life (HRQoL) states consisting of 5 dimensions (mobility, self-care, usual activities, pain/discomfort, anxiety/depression), each of which can take 1 of 5 responses. The responses record 5 levels of severity \[no problems, slight problems, moderate problems, severe problems, and extreme problems\] within a particular dimension. The scores will be the sum of scores from each dimension and can range from 5 (no problems) to 25 (extreme problems).

AE-QoL Total Score

Time frame · Up to 12 months from Index (day of the first homecare telephonic consultation/visit)

The Angioedema Quality of Life (AE-QoL) includes 17 items and 4 domains: functioning, fatigue/mood, fears/shame, and food. Raw scores from each domain will be linearly transformed to a total score of 0 to 100, with higher scores indicating a stronger impairment.