A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

Percentage of Participants Achieving Normalized Functioning Health Assessment Questionnaire - Disability Index (HAQ-DI) ≤0.5 at 12 Months of Therapy

Time frame · 12 Months

The HAQ-DI is a patient-reported outcome questionnaire that is used to measure disease associated disability as an assessment of physical function. It consists of 20 questions referring to 8 domains of functioning. Participants assess their degree of difficulty when performing the activities over the past week on a 4-item ordinal scale, ranging from 0, "without any difficulty," to 3, "unable to do." The scores of each of the 8 domains are summed and divided by 8. Higher scores indicate more limitations in physical function.

Percentage of Participants Achieving at Least a 10% Weight Loss at 12 Months of Therapy

Time frame · 12 Months

Percentage of participants achieving at least a 10% weight loss at 12 months of therapy.

Percentage of Participants Achieving Tender Joint Count (TJC) ≤1

Time frame · Month 6 and Month 12

Percentage of participants achieving TJC ≤1.

Percentage of Participants Achieving Swollen Joint Count (SJC) ≤1

Time frame · Month 6 and Month 12

Percentage of participants achieving SJC ≤1.

Percentage of Participants Achieving Body Surface Area (BSA) ≤3%

Time frame · Month 6 and Month 12

Percentage of participants achieving BSA ≤3%.

Percentage of Participants Achieving Patient Global Assessment of Disease Activity Numeric Rating Score (PaGADA NRS) of ≤2

Time frame · Month 6 and Month 12

The PaGADA NRS is an 11-point scale from 0 to 10 that is anchored by 2 verbal descriptors, "very well" and "very poor." Higher scores represent a higher level of disease activity.

Percentage of Participants Achieving Patient Pain Visual Analogue Scale (VAS) ≤15

Time frame · Month 6 and Month 12

The Patient's Assessment of Arthritis Pain is a single-item, patient-reported outcome instrument, used to access the current severity of participants' joint pain in relation to their PsA on a horizontal VAS of 0 to 100 mm. The Patient's Assessment of Arthritis Pain is anchored by 2 verbal descriptors, "no pain" and "as severe as can imagine."

Percentage of Participants Achieving Physician Global Assessment of Disease Activity (PhGADA) NRS ≤2

Time frame · Month 6 and Month 12

The PhGADA NRS is an 11-point scale anchored by 2 verbal descriptors, "none" and "extremely active disease."

Percentage of Participants Achieving HAQ-DI Sore ≤0.5 and at Least a 10% Weight Loss

Time frame · Month 6 and Month 12

The HAQ-DI is a patient-reported outcome questionnaire that is used to measure disease associated disability as an assessment of physical function. It consists of 20 questions referring to 8 domains of functioning. Participants assess their degree of difficulty when performing the activities over the past week on a 4-item ordinal scale, ranging from 0, "without any difficulty," to 3, "unable to do." The scores of each of the 8 domains are summed and divided by 8. Higher scores indicate more limitations in physical function.

Percentage of Participants With a Functional Assessment of Chronic Illness Therapy (FACIT) -Fatigue With ≥4-point Increase from Baseline

Time frame · Month 6 and Month 12

FACIT-F is a patient-reported, 13-item questionnaire that specifically assess the self-reported severity of fatigue and its impact upon daily activities and functioning. The FACIT-F uses 0 ("not at all") to 4 ("very much") Likert scale to assess fatigue and its impact in the past 7 days. Total score ranges from 0 to 52, based on a rating of 5-point Likert scale. Scores for negatively worded items are reversed, such that higher scores are better (that is, less fatigue).

Percentage of Participants With a Short-Form 36 (SF36) Physical Component Score (PCS) Minimum Clinically Important Difference (MCID)

Time frame · Month 6 and Month 12

The SF-36v2 acute form is a 36-item, generic, patient-completed measure designed to assess health-related quality of life with 8 health domains. Items are rated on 3-, 5-, or 6-point Likert scales. Each domain is individually scored by summing item responses and transforming them to a 0-100 scale. The eight domains are aggregated into two summary scores: Physical and Mental Component Summaries. Each summary score is norm based and presented in the form of T-scores, with a mean of 50 and a standard deviation of 10, with higher scores indicating better health status or functioning.

Percentage of Participants With a Short-Form 36 (SF36) Mental Component Score (MCS) MCID

Time frame · Month 6 and Month 12

The SF-36v2 acute form is a 36-item, generic, patient-completed measure designed to assess health-related quality of life with 8 health domains. Items are rated on 3-, 5-, or 6-point Likert scales. Each domain is individually scored by summing item responses and transforming them to a 0-100 scale. The eight domains are aggregated into two summary scores: Physical and Mental Component Summaries. Each summary score is norm based and presented in the form of T-scores, with a mean of 50 and a standard deviation of 10, with higher scores indicating better health status or functioning.