DRUG
Phenylephrine bolus 75 micrograms
After delivery of Baby during C section, patient will be administered 3 IU of Oxytocin over 3 minutes along with 75 micrograms of Phenylephrine Intravenously.
Comparison of Two Different Doses of Phenylephrine on Oxytocin Hemodynamic Effect
Status
Recruiting
Phase
Phase 4
Enrollment
112
Locations
1
Results
Not posted
Publications
0
Study summary
What the protocol is testing.
Cesarean section is one of the commonly performed surgical procedures in the world. Once baby is delivered during the surgical procedure anesthesiologist administer Oxytocin drug through IV cannula which helps the Uterus to contract so that excessive blood loss doesnt occur. But this is associated with fall in blood pressure frequently requiring administration of medications to treat low blood pressure. The most frequently used drug is phenylephrine which can administered along with oxytocin to prevent fall in blood pressure. This study will compare to different doses of Phenylephrine to prevent fall in blood pressure.
Full detailed description
Cesarean section is one of the most commonly performed surgical procedures worldwide. Following delivery of the neonate, oxytocin is routinely administered intravenously to promote uterine contraction and thereby reduce the risk of postpartum hemorrhage. However, oxytocin administration is frequently associated with maternal hypotension, which may necessitate pharmacological intervention. Phenylephrine, a selective α-adrenergic agonist, is commonly used to prevent or treat oxytocin-induced hypotension due to its vasoconstrictive properties. The optimal prophylactic dose of phenylephrine administered concurrently with oxytocin remains uncertain. This study aims to compare two different doses of phenylephrine for the prevention of hypotension following oxytocin administration during cesarean section.
Interventions
Treatment arms and agents.
DRUG
Phenylephrine bolus 50 micrograms
After delivery of Baby during C section, patient will be administered 3 IU of Oxytocin over 3 minutes along with 50 micrograms of Phenylephrine Intravenously.
Timeline
From registration to results.
First posted
Feb 19, 2026
Study start
Feb 13, 2026
Primary completion
Jul 13, 2026
Study completion
Jul 13, 2026
Results posted
Not reported
Registry updated
Feb 24, 2026
Outcomes
What the study measures.
Primary outcomes
Number of Hypotensive episodes
Time frame · Number of hypotensive episodes occuring upto 10 minutes after administration of Oxytocin and Phenylephrine
Hypotension will be defined as fall in Mean Arterial pressure by more than 20% from baseline value.
Secondary outcomes
Rescue Phenylephrine consumed
Time frame · This will be the total amount of Phenylephrine consumed to treat the hypotensive episodes occuring upto 10 minutes after administration of Oxytocin and Phenylephrine
Eligibility
Who can take part.
- Minimum age
- 20 Years
- Maximum age
- 40 Years
- Sex
- FEMALE
- Healthy volunteers
- Yes
Inclusion Criteria: \- Females having a singleton pregnancy Patients planned for elective cesarean section under spinal anesthesia Exclusion Criteria: * Patients having a placental abnormality * Patients taking beta-blocker and vasodilator therapy * Patients with hypertensive disorder
Study locations
1 registered sites.
Pakistan. Showing up to 24 locations stored in the fast local snapshot.
Department of Anesthesia, Holy Family Hospital, Rawalpindi
Rawalpindi, Punjab Province, Pakistan
Publications
Results and literature.
No PMID-linked publications were present in this registry snapshot.
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Put the record in context.
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