DRUG
Hypertonic 3% saline
Rapid Correction of hyponatremia
International Multi-center Retrospective Study of Patients With Serum Sodium ≤110 mmol/L to Determine the Relationship Between Osmotic Demyelination Syndrome (ODS) and Rapid Correction of Hyponatremia
Status
Enrolling by invitation
Phase
Not applicable
Enrollment
800
Locations
1
Results
Not posted
Publications
0
Study summary
What the protocol is testing.
Electronic medical records dating back as far as available for each center to identify patients admitted to the hospital with a serum sodium ≤110 mmol/l. Data on patient demographics, presenting symptoms, vital signs, laboratory findings, treatment given, sodium correction rates, presence of risk factors for osmotic demyelination syndrome (ODS) and outcomes including suspected and MRI-confirmed ODS, in-hospital death, and imaging confirmation of cerebral edema
Interventions
Treatment arms and agents.
Timeline
From registration to results.
First posted
May 8, 2026
Study start
Nov 1, 2023
Primary completion
Jun 30, 2026
Study completion
Jun 30, 2026
Results posted
Not reported
Registry updated
May 8, 2026
Outcomes
What the study measures.
Primary outcomes
Osmotic demyelination syndrome
Time frame · 1 to 14 days
Neurological deterioration after treatment of hyponatremia
MRI-confirmed Osmotic Demyelination Syndrome
Time frame · Within 30 days
Post treatment neurological deterioration with CPM and/or EPM
Secondary outcomes
Cerebral edema
Time frame · 2 days
Cerebral edema documented by imaging or death or respiratory arrest from suspected cerebral edema
Eligibility
Who can take part.
- Minimum age
- 18 Years
- Maximum age
- Not reported
- Sex
- ALL
- Healthy volunteers
- No
Inclusion Criteria: * Serum sodium ≤110 mmol/L at admission to the hospital Exclusion Criteria: * Blood glucose \>15 mmol/L, spurious laboratory dataa
Study locations
1 registered sites.
United States. Showing up to 24 locations stored in the fast local snapshot.
University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania, United States
Publications
Results and literature.
No PMID-linked publications were present in this registry snapshot.
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Related PeptideStat pages
Put the record in context.
Research pages describe evidence. Vendor pages, where available, describe independently tracked research-product listings and are not clinical recommendations.