BRE-06: Study to Increase Tolerance to Aromatase Inhibitors for Patients With Early-Stage Hormone Receptor Positive Breast Cancer Who Developed Hypoactive Sexual Desire Disorder

Inclusion Criteria: * Females 18 or older * Histologically-proven, resected, hormone receptor-positive (defined as estrogen receptor ≥1% and/or progesterone receptor (PgR)≥1% by immunohistochemistry at local institutions) early invasive breast cancer, stage I-III per American Joint Committee of Cancer (AJCC) 8th edition, regardless of Human Epidermal growth factor Receptor 2 (HER2) status * Completion of the following planned cancer treatments prior to registration: * Surgical resection of breast and nodal surgery; (NOTE: Reconstructive surgery does not have to be completed) * Adjuvant radiation therapy, if needed * Neoadjuvant and/or adjuvant chemotherapy if needed * Treatment with anti-HER2 agents is allowed * Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2. * Ability to swallow oral medication. * Provide written informed consent and fill out questionnaires * Willing to return to the enrolling institution for follow-up * Women of childbearing potential must not be pregnant or breastfeeding. A negative serum or urine pregnancy test is required per institutional practice guidelines. Women of childbearing potential will be required to use effective contraception from the time of consent until 30 days after the last dose of bupropion. Acceptable methods include hormonal contraception, intrauterine device, barrier methods with spermicide, or sterilization Exclusion Criteria: * Previous bilateral oophorectomy or ovarian irradiation; pregnant or lactating at the time of randomization or desiring pregnancy within 5 years. * History of psychiatric illnesses on active treatment * History or active suicidal thoughts or behaviors * Currently taking anti-depressants, anti-anxiety, or anti-psychotic medications. History of seizure disorder * History of bulimia or anorexia nervosa * Inhibitors or inducers of CYP2B6 * Drugs metabolized by CYP2D6 * Use of monoamine oxidase inhibitors (MAOI) * History of hypertension, regardless of control status. * History of angle closure glaucoma * Subjects taking levodopa, amantadine, methylene blue, and linezolid * Those with a hypersensitivity to bupropion, anastrozole, letrozole, exemestane, goserelin, or leuprolide. Currently receiving any of the following cancer-directed therapies: * Radiation therapy * Systemic therapy such as chemotherapy (standard or investigational) * Anti-HER2 agents are allowed