Pragmatic Trial to Study the Cost-Effectiveness of MyPhenome-RX Test to Guide Anti-Obesity Pharmacotherapy

Total Body Weight Loss (TBWL) at 6 Months %

Time frame · 6-Months

TWBL% at 6 months

TBWL% at 3 Months

Time frame · 3-months

TBWL% at 3 Months

TBWL% at 9 Months

Time frame · 9-Months

TBWL% at 9 Months

TBWL% at 12 Months

Time frame · 12-Months

TBWL% at 12 Months

TBWL% at 18 Months

Time frame · 18-Months

TBWL% at 18 Months

TBWL% at 24 Months

Time frame · 24-Months

TBWL% at 24 Months

Degree of Treatment Response

Time frame · 6-Months

6-Months: non-responsive (\<3% TBWL), partial responsive (3%-15% TBWL), successful (\>15%-20% TBWL) and highly successful (\>20% TBWL)

Cost of Treatment

Time frame · 3, 6, 9, 12, 18, 24 Months

Cost of Treatment

Cost-Effectiveness

Time frame · 3, 6, 9, 12, 18, 24 Months

Cost-Effectiveness Pharmacy resource utilization data will be collected during the study. Pharmacotherapy costs will be directly compared between control and intervention groups and compared to weight loss outcomes.

Patient Satisfaction

Time frame · 3, 6, 9, 12, 18, 24 Months

Client Satisfaction Questionnaire (CSQ-8): Given the design of the study, we will measure and evaluate patient satisfaction with a program of care rather than satisfaction with a specific medication. The satisfaction with the program will be evaluated with the adapted Client Satisfaction Questionnaire (CSQ-8). This is an 8-item measure that captures overall satisfaction with the care received, including perceived quality, whether care met patient needs, and willingness to recommend the program (each item score 1-4). The items will be lightly adapted to refer to weight management care with a total score ranging from 8 to 32 .