Current partner codePEPTIDESDE
NCT07738614·Phase 1·INTERVENTIONAL

A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight

Status

Not yet recruiting

Phase

Phase 1

Enrollment

56

Locations

2

Results

Not posted

Publications

0

Study summary

What the protocol is testing.

The main purpose of this study is to find out how significantly Eloralintide slows stomach emptying in participants who are overweight or obese. For each participant, the study will last approximately 21 weeks and will include 2 overnight stays in the clinical research unit (CRU) lasting between 4 and 8 days. There will be 13 other visits.

Interventions

Treatment arms and agents.

DRUG

Eloralintide

Administered SC

DRUG

Placebo

Administered SC

DRUG

Acetaminophen

Administered Oral Solution

Timeline

From registration to results.

  1. First posted

    Jul 31, 2026

  2. Study start

    Jul 2026

  3. Primary completion

    Dec 2026

  4. Study completion

    Dec 2026

  5. Results posted

    Not reported

  6. Registry updated

    Jul 31, 2026

Outcomes

What the study measures.

Primary outcomes

Acetaminophen Area Under the Concentration Versus Time Curve (AUC)

Time frame · Baseline to Day 65

Acetaminophen Maximum Observed Concentration (Cₘₐₓ)

Time frame · Baseline to Day 65

Acetaminophen Time to Maximum Observed Drug Concentration (tₘₐₓ)

Time frame · Baseline to Day 65

Secondary outcomes

Eloralintide AUC

Time frame · Baseline to Day 106

Eloralintide Cₘₐₓ

Time frame · Baseline to Day 106

Eligibility

Who can take part.

Minimum age
18 Years
Maximum age
65 Years
Sex
ALL
Healthy volunteers
Yes

Inclusion Criteria: * Have overweight or obesity, but are otherwise overtly healthy. * Have a body mass index (BMI) within the range of 27.0 to 45.0 kilograms (kg)/square meter (m²), inclusive. * Have had a stable body weight, with less than 5 percent (%) change during the 3-month period prior to screening. Exclusion Criteria: * Have been diagnosed with Type 1 or Type 2 diabetes mellitus, or have either of the following at screening * A fasting plasma glucose concentration greater than or equal to 126 milligrams (mg)/deciliter (dL) or 7.0 millimoles (mmol)/liter (L), or * Hemoglobin A1C (HbA1c) greater than or equal to 6.5% or 48 mmol/mole (mol). * Have a history or presence of psychiatric disorders, including a history of major depressive disorder or severe psychiatric disorders such as schizophrenia, and bipolar disorder, within the last 2 years. * Have received a glucagon-like peptide-1 (GLP-1) receptor agonist, glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonist, or GIP/GLP-1/glucagon receptor agonist within 60 days or 5 half-lives, whichever is longer, prior to screening. * Are in the judgment of the investigator, actively suicidal or deemed to be at significant risk for suicide.

Study locations

2 registered sites.

Singapore · United States. Showing up to 24 locations stored in the fast local snapshot.

ICON Early Phase Services

San Antonio, Texas, United States

Lilly Centre for Clinical Pharmacology

Singapore, Singapore

Publications

Results and literature.

No PMID-linked publications were present in this registry snapshot.

Primary links

Continue at the source.

Related trials

More studies on Eloralintide.

Related PeptideStat pages

Put the record in context.

Research pages describe evidence. Vendor pages, where available, describe independently tracked research-product listings and are not clinical recommendations.