DRUG
Eloralintide
Administered SC
Status
Not yet recruiting
Phase
Phase 1
Enrollment
56
Locations
2
Results
Not posted
Publications
0
Study summary
The main purpose of this study is to find out how significantly Eloralintide slows stomach emptying in participants who are overweight or obese. For each participant, the study will last approximately 21 weeks and will include 2 overnight stays in the clinical research unit (CRU) lasting between 4 and 8 days. There will be 13 other visits.
Interventions
DRUG
Administered SC
DRUG
Administered SC
DRUG
Administered Oral Solution
Timeline
First posted
Jul 31, 2026
Study start
Jul 2026
Primary completion
Dec 2026
Study completion
Dec 2026
Results posted
Not reported
Registry updated
Jul 31, 2026
Outcomes
Acetaminophen Area Under the Concentration Versus Time Curve (AUC)
Time frame · Baseline to Day 65
Acetaminophen Maximum Observed Concentration (Cₘₐₓ)
Time frame · Baseline to Day 65
Acetaminophen Time to Maximum Observed Drug Concentration (tₘₐₓ)
Time frame · Baseline to Day 65
Eloralintide AUC
Time frame · Baseline to Day 106
Eloralintide Cₘₐₓ
Time frame · Baseline to Day 106
Eligibility
Inclusion Criteria: * Have overweight or obesity, but are otherwise overtly healthy. * Have a body mass index (BMI) within the range of 27.0 to 45.0 kilograms (kg)/square meter (m²), inclusive. * Have had a stable body weight, with less than 5 percent (%) change during the 3-month period prior to screening. Exclusion Criteria: * Have been diagnosed with Type 1 or Type 2 diabetes mellitus, or have either of the following at screening * A fasting plasma glucose concentration greater than or equal to 126 milligrams (mg)/deciliter (dL) or 7.0 millimoles (mmol)/liter (L), or * Hemoglobin A1C (HbA1c) greater than or equal to 6.5% or 48 mmol/mole (mol). * Have a history or presence of psychiatric disorders, including a history of major depressive disorder or severe psychiatric disorders such as schizophrenia, and bipolar disorder, within the last 2 years. * Have received a glucagon-like peptide-1 (GLP-1) receptor agonist, glucose-dependent insulinotropic polypeptide (GIP)/GLP-1 receptor agonist, or GIP/GLP-1/glucagon receptor agonist within 60 days or 5 half-lives, whichever is longer, prior to screening. * Are in the judgment of the investigator, actively suicidal or deemed to be at significant risk for suicide.
Study locations
Singapore · United States. Showing up to 24 locations stored in the fast local snapshot.
ICON Early Phase Services
San Antonio, Texas, United States
Lilly Centre for Clinical Pharmacology
Singapore, Singapore
Publications
No PMID-linked publications were present in this registry snapshot.
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Related PeptideStat pages
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