POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS
University of Copenhagen · Postural Orthostatic Tachycardia Syndrome (POTS) · Healthy
Not applicable
Recruiting
30
2025-06
Evidence dashboardStudies since 1997Updated Jul 31, 2026
SincalideClinical Trials.
A source-linked view of every Sincalide study in the current snapshot—status, phase, enrollment, results, publications, locations and changes over time.
- Total trials
- 10
- Recruiting
- 1
- Completed
- 7
- Terminated
- 1
- Results posted
- 3
- Average enrollment
- 46
- Countries
- 4
- Highest phase
- Phase 4
Largest indexed study
252 participants · NCT00004414 →Developer / research origin
Bracco Diagnostics
Evidence summary
Activity is not efficacy.
Sincalide appears in 10 indexed studies: 1 recruiting, 7 completed and 3 with registry results posted. The highest registered development stage in this snapshot is Phase 4. These counts measure registry activity; they do not establish that Sincalide is safe or effective.
Review the design, endpoints, population, protocol changes, statistical analysis and publications before drawing conclusions.
Current studies
Recruiting or active
Completed studies
Finished records
Stopped studies
Withdrawn or terminated
NCT IDStudyPhase / statusEnrollmentUpdated
NCT IDStudyPhase / statusEnrollmentUpdated
Study to Assess the Way the Body Absorbs, Distributes, Breaks Down and Eliminates Radioactive BMS-986278 in Healthy Male Participants
Bristol-Myers Squibb · Healthy Volunteers
Phase 1
Completed
9
2022-06
Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids (BAs)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · Healthy Volunteers
Phase 3
Completed
31
2020-07
A Study Evaluating the Effect of Albiglutide on Gallbladder Emptying in Healthy Subjects
GlaxoSmithKline · Diabetes Mellitus, Type 2
Phase 4
Completed
20
2018-04
Dose Response of Intravenous Sincalide(CCK-8) for Gallbladder Emptying
Temple University · Healthy
Not applicable
Completed
60
2017-02
Impact of Two Genetic Variants of OATP1B3 or MRP2 or Rifampin on Systemic Disposition and Biological Efficacy of CCK-8
University Medicine Greifswald · Gastrointestinal Hormones
Phase 1
Completed
19
2015-07
The Impact of Gall Bladder Emptying and Bile Acids on the Human GLP-1-secretion
Filip Krag Knop · To Assess the Impact of Bile Acids on Human Glukagon-like-peptide-1 Secretion
Not applicable
Completed
10
2015-07
Showing 6 of 7 studies
NCT IDStudyPhase / statusEnrollmentUpdated
Mechanisms and Targeted Therapy of Airway Basal Cell Dysfunction in Bronchiolitis Obliterans Syndrome
Haikou Affiliated Hospital of Central South University Xiangya School of Medicine · Bronchiolitis Obliterans Syndrome (BOS)
Not applicable
Withdrawn
0
2026-07
Ultrasound for Diagnosis of Biliary Dyskinesia
Texas Tech University Health Sciences Center · Biliary Dyskinesia
Not applicable
Terminated
25
2010-11
Full study index
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10 matching studies
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Latest publications
Follow the paper trail.
PMID 18385466 ↗Someya N, Endo MY, Fukuba Y, Hayashi N. Blood flow responses in celiac and superior mesenteric arteries in the initial phase of digestion. Am J Physiol Regul Integr Comp Physiol. 2008 Jun;294(6):R1790-6. doi: 10.1152/ajpregu.00553.2007. Epub 2008 Apr 2.Linked from NCT07019519PMID 7614106 ↗Parker DR, Carlisle K, Cowan FJ, Corrall RJ, Read AE. Postprandial mesenteric blood flow in humans: relationship to endogenous gastrointestinal hormone secretion and energy content of food. Eur J Gastroenterol Hepatol. 1995 May;7(5):435-40.Linked from NCT07019519PMID 31369335 ↗Randall EB, Billeschou A, Brinth LS, Mehlsen J, Olufsen MS. A model-based analysis of autonomic nervous function in response to the Valsalva maneuver. J Appl Physiol (1985). 2019 Nov 1;127(5):1386-1402. doi: 10.1152/japplphysiol.00015.2019. Epub 2019 Aug 1.Linked from NCT07019519PMID 29549458 ↗Mehr SE, Barbul A, Shibao CA. Gastrointestinal symptoms in postural tachycardia syndrome: a systematic review. Clin Auton Res. 2018 Aug;28(4):411-421. doi: 10.1007/s10286-018-0519-x. Epub 2018 Mar 16.Linked from NCT07019519PMID 35232225 ↗Breier NC, Paranjape SY, Scudder S, Mehr SE, Diedrich A, Flynn CR, Okamoto LE, Hartmann B, Gasbjerg LS, Shibao CA. Worsening Postural Tachycardia Syndrome Is Associated With Increased Glucose-Dependent Insulinotropic Polypeptide Secretion. Hypertension. 2022 May;79(5):e89-e99. doi: 10.1161/HYPERTENSIONAHA.121.17852. Epub 2022 Mar 2.Linked from NCT07019519PMID 28258126 ↗Koffert J, Honka H, Teuho J, Kauhanen S, Hurme S, Parkkola R, Oikonen V, Mari A, Lindqvist A, Wierup N, Groop L, Nuutila P. Effects of meal and incretins in the regulation of splanchnic blood flow. Endocr Connect. 2017 Apr;6(3):179-187. doi: 10.1530/EC-17-0015. Epub 2017 Mar 3.Linked from NCT07019519PMID 28667118 ↗Asmar M, Asmar A, Simonsen L, Gasbjerg LS, Sparre-Ulrich AH, Rosenkilde MM, Hartmann B, Dela F, Holst JJ, Bulow J. The Gluco- and Liporegulatory and Vasodilatory Effects of Glucose-Dependent Insulinotropic Polypeptide (GIP) Are Abolished by an Antagonist of the Human GIP Receptor. Diabetes. 2017 Sep;66(9):2363-2371. doi: 10.2337/db17-0480. Epub 2017 Jun 30.Linked from NCT07019519PMID 20547981 ↗Asmar M, Simonsen L, Madsbad S, Stallknecht B, Holst JJ, Bulow J. Glucose-dependent insulinotropic polypeptide may enhance fatty acid re-esterification in subcutaneous abdominal adipose tissue in lean humans. Diabetes. 2010 Sep;59(9):2160-3. doi: 10.2337/db10-0098. Epub 2010 Jun 14.Linked from NCT07019519
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