Colivelin
Also known as: ADNF-Humanin hybrid
Colivelin simultaneously activates an ADNF-mediated CaMKIV pathway and a Humanin-mediated JAK2/STAT3 pathway to suppress neuronal death in cell and rodent models.
This page is a structured profile. Narrative evidence, dosing context and FAQs live on the research guide — not duplicated here as a second full article.
- Drug class
- Synthetic neuroprotective hybrid peptide (ADNF + Humanin derivative)
- Primary targets
- Humanin receptor / JAK2-STAT3 pro-survival pathway, ADNF / Ca2+-calmodulin-dependent protein kinase IV (CaMKIV) pathway
- Dose reference
- No established human dose; preclinical rodent studies used roughly 10 pmol to 1 nmol given intracerebroventricularly, plus intraperitoneal and intranasal experiments (research figures only, not recommendations).
- Half-life
- Not established in humans; expected to be short as an unmodified peptide.
- Developer / origin
- Nishimoto, Matsuoka, Chiba and colleagues, Keio University School of Medicine (Tokyo)
- Reference year
- 2005
- Evidence score
- 2/5 - Preclinical only
Preclinical only
Colivelin shows consistent, potent neuroprotection in cell-culture and rodent models of Alzheimer's disease and ALS, but there is no human clinical or safety evidence and it has never entered registered human trials.
Mostly animal, ex vivo, cell, or indirect evidence.
Evidence basis
- Femtomolar neuroprotection against amyloid-beta and familial AD mutant toxicity in vitro (Chiba et al., J Neurosci 2005)
- Improved memory and reduced hippocampal neuronal loss in Alzheimer's mouse models via ICV, IP and intranasal routes (Chiba 2005; Yamada 2008)
- Prolonged survival and improved motor performance in G93A-SOD1 ALS mice (Chiba et al., BBRC 2006)
- No human pharmacokinetic, efficacy, or safety data; no registered clinical trials despite ~two decades of preclinical work
Key references
- PubMedDevelopment of a femtomolar-acting humanin derivative named colivelin (Chiba et al., J Neurosci 2005)
- PubMedColivelin prolongs survival of an ALS model mouse (Chiba et al., BBRC 2006)
- PubMedNasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease (Yamada et al., Neuropsychopharmacology 2008)
How to read this entry
Dose references and half-life values are pulled from trial protocols, labels, reviews, or published summaries where available. They are context for research and comparison, not a personal dosing recommendation.
Status matters: approved drugs have regulated indications; investigational compounds are still being studied; research-only peptides do not have established human dosing, safety, or efficacy for consumer use.
Colivelin guides
Read the matching guide or adjacent research pages for more context.
Peptide calculators
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