PEPTIDESTAT
ApprovedClinical / approved drugIntravenousEvidence 4/5

Secretin

Also known as: ChiRhoStim, human secretin

Secretin binds the secretin receptor on pancreatic duct cells, raising cAMP and opening CFTR channels to drive secretion of bicarbonate-rich pancreatic fluid that is measured during diagnostic testing.

Read guideBuy / compare source
Secretin
Drug class
Gastrointestinal peptide hormone (diagnostic agent); secretin-receptor agonist
Primary targets
Secretin receptor (SCTR), Pancreatic duct cells, CFTR channel, Gastrin secretion (G cells)
Dose reference
FDA label reference doses (diagnostic, not recommendations): 0.2 mcg/kg IV over 1 minute for pancreatic exocrine function testing or ERCP; 0.4 mcg/kg IV over 1 minute for gastrinoma testing.
Half-life
About 45 minutes per the ChiRhoStim label (synthetic human secretin); native secretin plasma half-life measured at roughly 4 minutes by radioimmunoassay.
Developer / origin
ChiRhoClin, Inc. (Burtonsville, MD)
Reference year
2004
Evidence score
4/5 - Approved diagnostic agent; therapeutic uses unsupported

Approved uses

  • Stimulation of pancreatic secretions (including bicarbonate) to aid diagnosis of pancreatic exocrine dysfunction
  • Stimulation of gastrin secretion to aid diagnosis of gastrinoma
  • Stimulation of pancreatic secretions to facilitate identification of the ampulla of Vater and accessory papilla during ERCP
Evidence 4/5

Approved diagnostic agent; therapeutic uses unsupported

Secretin (ChiRhoStim, human secretin) is FDA-approved as an intravenous diagnostic peptide for pancreatic exocrine function testing, gastrinoma testing, and ERCP duct identification, with a well-defined secretin-receptor/CFTR mechanism. Its mechanism and diagnostic performance are well established, but attempts to use it therapeutically (notably for autism) failed in randomized trials and a Cochrane review.

Investigational compound with human randomized or phase 2/3 evidence.

Evidence basis

  • FDA-approved label (NDA 021256) and DailyMed prescribing information define indications, reference doses, and pharmacokinetics
  • Pancreapedia and pancreatic physiology literature describe the secretin receptor and bicarbonate-secretion mechanism
  • Radioimmunoassay study (Kolts & McGuigan) and label PK data establish half-life values
  • NEJM 1999 RCT (Sandler et al.) and Cochrane review of 16 RCTs (>900 children) found no benefit for autism

How to read this entry

Dose references and half-life values are pulled from trial protocols, labels, reviews, or published summaries where available. They are context for research and comparison, not a personal dosing recommendation.

Status matters: approved drugs have regulated indications; investigational compounds are still being studied; research-only peptides do not have established human dosing, safety, or efficacy for consumer use.

Secretin guides

Read the matching guide or adjacent research pages for more context.

Secretin Peptide: ChiRhoStim, Pancreatic and Gastrinoma Diagnostic UseSecretin is an FDA-approved diagnostic peptide hormone used to stimulate pancreatic and gastrin secretion, not a wellness or performance compound.Abaloparatide Peptide: Tymlos, PTHrP Analog Uses and Safety LimitsAbaloparatide is an FDA-approved PTHrP(1-34) analog peptide that builds bone in high-risk osteoporosis, backed by the ACTIVE and ATOM trials with clear duration and safety limits.Atosiban Peptide: Tractocile, Oxytocin Antagonist Tocolytic for Preterm LaborAtosiban is an EU-approved oxytocin and vasopressin receptor antagonist peptide used intravenously as a short-term tocolytic to delay preterm labor.Bivalirudin Peptide: Angiomax Direct Thrombin Inhibitor GuideBivalirudin is an FDA-approved, hirudin-derived bivalent direct thrombin inhibitor used as a short-acting intravenous anticoagulant during percutaneous coronary intervention.

Peptide calculators

Use calculators for concentration, unit conversion and repeated-dose accumulation math.

Peptide reconstitution calculatorCalculate concentration, draw volume and syringe units from vial strength and BAC water.Open toolPeptide accumulation calculatorModel repeated dosing schedules with half-life, interval, peak and trough estimates.Open toolPeptide unit converterConvert mg, mcg, optional IU and syringe units from one reconstituted vial setup.Open toolPeptide chemistry calculatorAnalyze sequence length, molecular weight, composition, charge, hydropathy and notation.Open tool

Compare with related peptides

Stay inside the same research category and compare mechanism, status and evidence quality.

Larazotide

Larazotide acetate, AT-1001

2/5
Clinical / approved drugInvestigational

An oral, gut-restricted peptide that antagonizes zonulin signaling to limit gluten-driven intestinal tight-junction permeability in celiac disease.

DetailsGuide

Lanreotide

Somatuline Depot, Somatuline Autogel

5/5
Clinical / approved drugApproved

Lanreotide binds with high affinity to somatostatin receptors 2 and 5, mimicking native somatostatin to suppress growth hormone, IGF-1 and various neuroendocrine and gut hormones.

DetailsGuide

Teriparatide

Forteo, Bonsity, PTH 1-34

4/5
Clinical / approved drugApproved

Once-daily injection produces intermittent activation of the PTH1 receptor on osteoblasts, preferentially stimulating bone formation over resorption to increase bone mass.

DetailsGuide
4/5
Clinical / approved drugApproved

Abaloparatide is a PTHrP(1-34) analog that agonizes the PTH1 receptor with preference for its transient RG conformation, activating cAMP signaling to stimulate osteoblast-driven new bone formation.

DetailsGuide

Research & educational purposes only

The information on PeptideStat is for educational and research purposes only and is not medical advice. Many peptides discussed are research compounds not approved for human use. Always consult a qualified healthcare professional before making any health decisions. Articles may contain affiliate links — we may earn a commission at no extra cost to you.