A Study Of Effect Of Secretin For In Injection (Chirostim) On Pancreatic Fluid Composition In Healthy Subjects
Mayo Clinic · Exocrine Pancreatic Insufficiency · Chronic Pancreatitis
Phase 4
Recruiting
24
2026-07
Evidence dashboardStudies since 1999Updated Jul 31, 2026
SecretinClinical Trials.
A source-linked view of every Secretin study in the current snapshot—status, phase, enrollment, results, publications, locations and changes over time.
- Total trials
- 53
- Recruiting
- 5
- Completed
- 26
- Terminated
- 6
- Results posted
- 8
- Average enrollment
- 279
- Countries
- 9
- Highest phase
- Phase 4
Largest indexed study
9,000 participants · NCT02000089 →Developer / research origin
Multiple
Evidence summary
Activity is not efficacy.
Secretin appears in 53 indexed studies: 5 recruiting, 26 completed and 8 with registry results posted. The highest registered development stage in this snapshot is Phase 4. These counts measure registry activity; they do not establish that Secretin is safe or effective.
Review the design, endpoints, population, protocol changes, statistical analysis and publications before drawing conclusions.
Current studies
Recruiting or active
Completed studies
Finished records
Stopped studies
Withdrawn or terminated
NCT IDStudyPhase / statusEnrollmentUpdated
Secretin in Ex-situ Liver Perfusion
Erasmus Medical Center · Liver Transplantation
Phase 1 / Phase 2
Enrolling by invitation
20
2026-06
Imaging Biomarkers of Pancreatic Function and Disease
Children's Hospital Medical Center, Cincinnati · Pancreatitis · Diabetes Mellitus
Phase 4
Enrolling by invitation
195
2026-03
Secretin in Refeeding
University of California, Los Angeles · Anorexia in Adolescence
Not applicable
Recruiting
10
2026-02
Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies
M.D. Anderson Cancer Center · Pancreatitis
Not applicable
Recruiting
2,345
2025-10
The Cancer of the Pancreas Screening-5 CAPS5)Study
Johns Hopkins University · Pancreas Cancer · Peutz-Jeghers Syndrome (PJS)
Phase 3
Recruiting
9,000
2025-10
Showing 6 of 12 studies
NCT IDStudyPhase / statusEnrollmentUpdated
Trial of Indomethacin in Chronic Pancreatitis
Mayo Clinic · Chronic Pancreatitis
Phase 1 / Phase 2
Completed
27
2024-09
Safety Study of the Drug RG1068 in Patients With Obsessive Compulsive Disorder
Indiana University · Obsessive Compulsive Disorder (OCD)
Phase 2
Completed
12
2024-02
A Proof-of-Concept Study Evaluating LINFU™
Adenocyte, LLC · Pancreas Adenocarcinoma · Dysplasia
Not applicable
Completed
12
2024-02
Intraductal Secretin Stimulation Test: What Is the Proper Collection Time?
Indiana University · Cholangiopancreatography, Endoscopic Retrograde
Not applicable
Completed
8
2023-09
Optical and Biochemical Biomarkers in Early Pancreatic Cancer
Mayo Clinic · Pancreatic Cancer
Not applicable
Completed
346
2023-06
BreathID® Test: A Non-invasive Modality to Detect Pancreatic Exocrine Insufficiency
Meridian Bioscience, Inc. · Chronic Pancreatitis · Healthy Volunteers
Phase 2
Completed
33
2022-12
Showing 6 of 26 studies
NCT IDStudyPhase / statusEnrollmentUpdated
Recurrent Abdominal Pain and Exocrine Pancreatic Insufficiency
Orlando Health, Inc. · Abdominal Pain · Irritable Bowel Syndrome
Phase 3
Terminated
27
2024-04
Secretin-Assisted Computed Tomography Scan and Magnetic Resonance Imaging in Improving Pancreatic Tumor Conspicuity
University Hospitals Cleveland Medical Center · Pancreas Cancer
Early Phase 1
Withdrawn
0
2022-06
Efficacy of Secretin MRCP in the Diagnosis and Follow up of Auto Immune Pancreatitis
Johns Hopkins University · Cellular Diagnosis, Pancreatic Cancer · Autoimmune Pancreatitis
Not applicable
Withdrawn
0
2019-01
Secretin-enhanced Magnetic Resonance Imaging (S-MRI) for Pancreatic Cancer Detection
Elizabeth Hecht · Pancreatic Cancer · Intraductal Papillary Mucinous Neoplasm
Not applicable
Withdrawn
0
2016-06
Secretin-enhanced Magnetic Resonance Cholangiopancreatography (S-MRCP) and Pancreatic Function Following Surgery
Columbia University · Pancreatic Cancer
Not applicable
Withdrawn
0
2015-04
Secretin (ChiRhoStim) Pancreas Perfusion for Pancreatic Adenocarcinoma
Mayo Clinic · Pancreatic Cancer
Phase 1 / Phase 2
Terminated
4
2013-06
Showing 6 of 11 studies
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53 matching studies
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Latest publications
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PMID 36721302 ↗de Jong IEM, Bodewes SB, van Leeuwen OB, Oosterhuis D, Lantinga VA, Thorne AM, Lascaris B, van den Heuvel MC, Wells RG, Olinga P, de Meijer VE, Porte RJ. Restoration of Bile Duct Injury of Donor Livers During Ex Situ Normothermic Machine Perfusion. Transplantation. 2023 Jun 1;107(6):e161-e172. doi: 10.1097/TP.0000000000004531. Epub 2023 May 23.Linked from NCT07651748PMID 36740047 ↗Eden J, Sousa Da Silva R, Cortes-Cerisuelo M, Croome K, De Carlis R, Hessheimer AJ, Muller X, de Goeij F, Banz V, Magini G, Compagnon P, Elmer A, Lauterio A, Panconesi R, Widmer J, Dondossola D, Muiesan P, Monbaliu D, de Rosner van Rosmalen M, Detry O, Fondevila C, Jochmans I, Pirenne J, Immer F, Oniscu GC, de Jonge J, Lesurtel M, De Carlis LG, Taner CB, Heaton N, Schlegel A, Dutkowski P. Utilization of livers donated after circulatory death for transplantation - An international comparison. J Hepatol. 2023 May;78(5):1007-1016. doi: 10.1016/j.jhep.2023.01.025. Epub 2023 Feb 4.Linked from NCT07651748PMID 25939487 ↗Orman ES, Mayorga ME, Wheeler SB, Townsley RM, Toro-Diaz HH, Hayashi PH, Barritt AS 4th. Declining liver graft quality threatens the future of liver transplantation in the United States. Liver Transpl. 2015 Aug;21(8):1040-50. doi: 10.1002/lt.24160.Linked from NCT07651748PMID 26831547 ↗Nemes B, Gaman G, Polak WG, Gelley F, Hara T, Ono S, Baimakhanov Z, Piros L, Eguchi S. Extended-criteria donors in liver transplantation Part II: reviewing the impact of extended-criteria donors on the complications and outcomes of liver transplantation. Expert Rev Gastroenterol Hepatol. 2016 Jul;10(7):841-59. doi: 10.1586/17474124.2016.1149062. Epub 2016 Mar 2.Linked from NCT07651748PMID 35286759 ↗van Leeuwen OB, Bodewes SB, Lantinga VA, Haring MPD, Thorne AM, Bruggenwirth IMA, van den Berg AP, de Boer MT, de Jong IEM, de Kleine RHJ, Lascaris B, Nijsten MWN, Reyntjens KMEM, de Meijer VE, Porte RJ. Sequential hypothermic and normothermic machine perfusion enables safe transplantation of high-risk donor livers. Am J Transplant. 2022 Jun;22(6):1658-1670. doi: 10.1111/ajt.17022. Epub 2022 Apr 18.Linked from NCT07651748PMID 23720296 ↗Tabibian JH, Masyuk AI, Masyuk TV, O'Hara SP, LaRusso NF. Physiology of cholangiocytes. Compr Physiol. 2013 Jan;3(1):541-65. doi: 10.1002/cphy.c120019.Linked from NCT07651748PMID 21932391 ↗Hohenester S, Wenniger LM, Paulusma CC, van Vliet SJ, Jefferson DM, Elferink RP, Beuers U. A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes. Hepatology. 2012 Jan;55(1):173-83. doi: 10.1002/hep.24691.Linked from NCT07651748PMID 36191836 ↗Yadav D, Askew RL, Palermo T, Li L, Andersen DK, Chen M, Fisher WE, Fogel EL, Forsmark CE, Hart PA, Othman MO, Pandol SJ, Park WG, Topazian MD, Van Den Eeden SK, Vege SS, Yang Y, Serrano J, Conwell DL; Consortium for the Study of Chronic Pancreatitis, Diabetes; Pancreatic Cancer (CPDPC). Association of Chronic Pancreatitis Pain Features With Physical, Mental, and Social Health. Clin Gastroenterol Hepatol. 2023 Jul;21(7):1781-1791.e4. doi: 10.1016/j.cgh.2022.09.026. Epub 2022 Oct 1.Linked from NCT03099850
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