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Research onlyLongevitySubcutaneousEvidence 2/5

Vesugen

Also known as: Lys-Glu-Asp tripeptide

Vesugen (Lys-Glu-Asp) is proposed to enter the cell nucleus and bind DNA and histones in gene promoter regions, modulating expression of vascular, senescence and neurogenesis genes rather than acting as a classical receptor agonist.

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Vesugen
Drug class
Short-peptide bioregulator (synthetic tripeptide)
Primary targets
Gene promoter regions / DNA, Histone proteins, Endothelin-1 expression, Connexins, Sirtuin-1 (SIRT1)
Dose reference
No approved or established human dose; research-only. Figures cited for Russian supplement courses or reconstituted research vials are not dosing recommendations.
Half-life
No published human pharmacokinetic data; as an ultrashort tripeptide it is expected to clear from plasma within minutes.
Developer / origin
St. Petersburg Institute of Bioregulation and Gerontology (V. Khavinson and colleagues)
Reference year
2003
Evidence score
2/5 - Preclinical with very limited human evidence
Evidence 2/5

Preclinical with very limited human evidence

Vesugen (KED) has reproducible in vitro and rodent gene-expression signals from the Khavinson research network, but human data are minimal, uncontrolled, single-network, and unreplicated, with no regulatory approval and no robust pharmacokinetic dataset.

Mostly animal, ex vivo, cell, or indirect evidence.

Evidence basis

  • In vitro studies report KED alters senescence (p16, p21) and neurogenesis (NES, GAP43) gene expression and restores neuronal spine counts in Alzheimer's-disease cell models
  • A 2021 Khavinson-group systematic review aggregates cardiovascular, neuroprotective and geroprotective claims, all mechanistic rather than outcome-based
  • Human evidence is limited to a reported improvement in memory and attention in elderly subjects, without transparent randomized controlled trial design
  • No FDA/EMA review, no independent Western trial, and no published human pharmacokinetic profile

How to read this entry

Dose references and half-life values are pulled from trial protocols, labels, reviews, or published summaries where available. They are context for research and comparison, not a personal dosing recommendation.

Status matters: approved drugs have regulated indications; investigational compounds are still being studied; research-only peptides do not have established human dosing, safety, or efficacy for consumer use.

Vesugen guides

Read the matching guide or adjacent research pages for more context.

Vesugen Peptide: Lys-Glu-Asp Vascular Bioregulator Evidence and LimitsVesugen is a research-only Khavinson tripeptide (Lys-Glu-Asp) with gene-expression and vascular claims but very limited primary human evidence and no regulatory approval.Best Peptides for Hair Growth: Evidence, Protocols, and LimitsA practical hair-growth hub: which peptide and peptide-adjacent ingredients have real rationale, what is only cosmetic, and what still beats them for evidence.Bryan Johnson Hair Protocol: Peptide Shampoo, Serum, Laser Cap & MinoxidilThe Bryan Johnson hair protocol: Blueprint peptide shampoo, peptide serum, laser cap, minoxidil, ingredient roles, and supporting research.Argireline Peptide: Acetyl Hexapeptide-8 and the SNARE Wrinkle ClaimArgireline is a topical cosmetic hexapeptide marketed as topical Botox, with modest, mostly industry-funded wrinkle evidence and a major skin-permeation limitation.

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The information on PeptideStat is for educational and research purposes only and is not medical advice. Many peptides discussed are research compounds not approved for human use. Always consult a qualified healthcare professional before making any health decisions. Articles may contain affiliate links — we may earn a commission at no extra cost to you.