Efficacy and Safety Study of Tesamorelin in Chronic Obstructive Pulmonary Disease (COPD) Subjects With Muscle Wasting

Inclusion Criteria: * Male or female subjects aged 40-75 years (y) inclusive * Documented diagnosis of moderate to very severe COPD (GOLD stage 2, 3, or 4) * Stable COPD (i.e., no exacerbation) for at least 6 weeks prior to screening * Able to participate in a supervised exercise training program * Evidence of muscle wasting Exclusion Criteria * Participation in a pulmonary rehabilitation program or in any supervised exercise program during the 4 months prior to screening * More than 4 exacerbations in the year prior to screening * Life-threatening exacerbation in the year prior to screening * Requirement for long-term oxygen therapy (\> 12 hours of oxygen per day) * Critical illness or co-morbid conditions that may interfere with study conduct or endpoint measurements * Use of agents known to increase lean body mass within 3 months prior to screening * Hypopituitarism, history of pituitary tumor/surgery, head irradiation, or severe head trauma