A Study to Evaluate Dose Responses of Efficacy and Safety of ASP0456 in Patient With Chronic Constipation

Inclusion Criteria: * Patient who had SBM\* (Spontaneous bowel movement) less than 3 times per week, more than six months prior to the provisional registration * \*Defecation without procedure of laxative, suppository, enema, or stool extraction on the day or preceding day of the defecation * Patient who was affected with one or more following symptoms before more than six months of provisional registration: * Straining during at least 25% of defecations * Lumpy or hard stools in at least 25% of defecations * Sensation of incomplete evacuation for at least 25% of defecations * Loose stools are rarely present without the use of laxatives more than six months prior to the provisional registration. * Patients who had pancolonoscopy or contrast enema (or sigmoidoscopy) after the onset of chronic constipation symptom and had no organic changes Exclusion Criteria: * Patient who has met IBS-C diagnostic criteria from Rome III more than six months prior to provisional registration. Meaning that patient who had recurrent abdominal pain or discomfort at least 3 days/month in last 3 months associated with two or more of the following, and patient who was affected with following IBS symptoms more than six months prior to the provisional registration: * Improvement with defecation * Onset associated with a change in frequency of stool * Onset associated with a change in form (appearance) of stool * Patient with history of surgical resection of stomach, gallbladder, small intestine, or large intestine (excluding resection of appendicitis and benign polyp) * Patient with history or current evidence of inflammatory bowel disease (Crohn's disease or ulcerative colitis) * Patient with history or current evidence of ischemic colitis * Patient currently affected by infectious enteritis * Patient currently affected by hyperthyroidism or hypothyroidism * Patient with apparent mechanical obstruction (i.e. patient with ileus caused by hernia) * Patient with mega colon or mega rectum * Patient currently affected by constipation due to anorectal dysfunction * Patient currently affected by drug induced constipation. * Patient with constipation due to other organic disease * Patient currently affected by active peptic ulcer * In the case of a female, the one currently affected by endometriosis or uterine adenomyosis * Patient with high depression or anxiety considered to influence drug evaluation * Patient with history of abuse of drug or alcohol within a year before consent acquisition, or with current abuse * Patient who used or underwent or will use or undergo drug/therapy/test prohibited to combine 3 days before the start of bowel habit observation period (Day -17) or thereafter (however, patient who used or underwent restricted drug/therapy according to Protocol may be enrolled provisionally) * Patient with history or current evidence of malignant tumor * Patient currently affected by serious cardiovascular disease, respiratory disease, kidney disease, hepatic disease, gastrointestinal disease (excluding CC), hemorrhagic disease, or neural/mental disease * Patient with history of drug allergy