OTHER
Blood sampling and Quality of life questionnaire.
Blood sampling and Quality of life questionnaire.
Status
Completed
Phase
Not applicable
Enrollment
150
Locations
1
Results
Not posted
Publications
0
Study summary
This is a prospective cohort study of patients with Heart Failure with an eighteen-month follow-up aimed to collect all demographic, clinical, biological and para-clinical data to study population characteristics, assess prognosis markers and occurrence of HF treatment side effects. Congestive Heart failure is a frequent pathology and its prevalence increases with age. Its prognosis stays pejorative despite years of major therapeutical progress. In recent trials, all-cause mortality rates at 1-year reach up to 20% and 50% at 5 years. Medical care of congestive heart failure is based on precise international recommendations. The association of Beta-Blockers, renin-angiotensin system blockers, mineralocorticoid receptor antagonists, represent the basis of the pharmacological treatment. Cardiac resynchronization treatment and implantable cardioverter-defibrillator are additional efficient treatments that reduce events in appropriately selected patients. Despite these improvements, the prognostic of congestive heart failure in registers is worse than those observed in randomized trials. This can be explained by differences in congestive heart failure patient populations and/or by a less rigorous medical care where treatments are not optimized. The evaluation of medical care in congestive heart failure is today of utmost importance. Integrating new pharmacological molecules, medical devices and the application of new recommendations have major interest for documentation and practical changes. The main objective of this cohort will be to evaluate the evolution of the 12-month quality of life score of a HF patient and the characteristics and treatments associated with it.
Interventions
OTHER
Blood sampling and Quality of life questionnaire.
Timeline
First posted
Feb 6, 2018
Study start
Dec 15, 2017
Primary completion
Jan 16, 2024
Study completion
Jan 16, 2024
Results posted
Not reported
Registry updated
Nov 18, 2024
Outcomes
Change from Baseline Quality of life questionnaire : EuroQol (EQ-5D) at 12 months
Time frame · 12 months
Measurement of quality of life of patients with heart failure: patient will answer to this questionnaire (Mobility, Autonomy of the person, Current activities, Pain ,Anxiéty/Depression) ) at baseline and at 12th month visit. The evolution between these two scores will be analysed .
Renal function : glomerular filtration rate
Time frame · Baseline
Assessing the renal function evolution of patients with heart failure the glomerular filtration rate will be calculated according to CKD-EPI (Chronic Kidney Disease - Epidemiology Collaboration) formula.
Renal function : glomerular filtration rate
Time frame · 2 months
Assessing the renal function evolution of patients with heart failure the glomerular filtration rate will be calculated according to CKD-EPI (Chronic Kidney Disease - Epidemiology Collaboration) formula.
NT-proBNP
Time frame · 18 months
Measure of NT-proBNP will be done at 18th month in order to correlate the effect of low blood pression and renal function decreasing on NT-proBNP variability
number of death (all-cause)
Time frame · 18 months
number of all cardiovascular cause death
Time frame · 18 months
number all unscheduled hospitalization for heart failure
Time frame · 18 months
number of stroke
Time frame · 18 months
nonfatal myocardial infarction
Time frame · 18 months
cardiac assistance or heart transplantation
Time frame · 18 months
symptomatic hypotension
Time frame · 18 months
Eligibility
Inclusion Criteria: * Patients with congestive heart failure confirmed during * Hospitalization for cardiac decompensation * A medical follow-up for stable congestive heart failure with at least one cardiac decompensation event * NT-proBNP \> 500 ng/l in the month before Baseline (or BNP \> 150 ng/l) * NYHA ≥ 2 * Aged over 18 * Signature of the informed consent Exclusion Criteria: * Life expectancy shorter than a month * Patients on long term assistance or with heart transplant * Impossibility to give patients clear information * Loss of autonomy, dementia, major dependence * Patients without health coverage * Patient with no legal protection * Pregnant woman
Study locations
France. Showing up to 24 locations stored in the fast local snapshot.
Hospices Civils de Lyon - Hôpital Louis Pradel, Centre d'Investigation Clinique
Lyon, France
Publications
No PMID-linked publications were present in this registry snapshot.
Related trials
Universidade do Porto · Heart Failure
Not applicable
Recruiting
160
2026-07
Boston Medical Center · Congestive Heart Failure · Volume Overload
Not applicable
Not yet recruiting
200
2026-06
Norfolk and Norwich University Hospitals NHS Foundation Trust · Vascular Surgical Procedure
Not applicable
Recruiting
200
2026-06
China National Center for Cardiovascular Diseases · AKI - Acute Kidney Injury · Cardiac Surgical Procedures
Phase 4
Not yet recruiting
694
2026-06
Cambridge University Hospitals NHS Foundation Trust · Heart Failure
Not applicable
Recruiting
250
2026-05
Chulalongkorn University · Acute Kidney Failure Stage 3
Not applicable
Completed
100
2026-05
Ottawa Heart Institute Research Corporation · Chronic Right-Sided Heart Failure · Pulmonary Arterial Hypertension
Phase 4
Completed
15
2026-05
Novartis · Chronic Heart Failure and Reduced Ejection Fraction (HFrEF)
Not applicable
Completed
236
2026-04
Related PeptideStat pages
Research pages describe evidence. Vendor pages, where available, describe independently tracked research-product listings and are not clinical recommendations.