DRUG
Oxytocin
Oxytocin given in a combined regimen: after delivery 10 IE of oxytocin are applied intramyometrially and 10 IE of oxytocin are given over an infusion of 1000ml of 0.9% NaCL over 12 hours intravenously.
Oxytocin i.m./i.v. Versus Carbetocin i.v. in Elective Cesarean Sections
Status
Completed
Phase
Phase 4
Enrollment
550
Locations
1
Results
Not posted
Publications
0
Study summary
What the protocol is testing.
Objective is to proof non-inferiority of intramyometrial and intravenous oxytocin application compared to intravenous carbetocin for prevention of postpartum hemorrhage in planned, uncomplicated cesarean deliveries.
Interventions
Treatment arms and agents.
DRUG
Carbetocin
Carbetocin is given 0.1mg intravenously as a bolus after delivery.
Timeline
From registration to results.
First posted
Aug 29, 2018
Study start
Aug 7, 2018
Primary completion
Jan 10, 2022
Study completion
Jan 10, 2022
Results posted
Not reported
Registry updated
May 24, 2023
Outcomes
What the study measures.
Primary outcomes
incidence of women with a delta hemoglobin ≥ 30g/l.
Time frame · 48 hours
Delta hemoglobin is defined as the difference of the hemoglobin at admission minus the hemoglobin after delivery, usually 24-48 hours after the delivery.
Secondary outcomes
adverse maternal outcome parameters
Time frame · 15 days
decrease in hemoglobin (delta hemoglobin, in g/l)
adverse maternal outcome parameters
Time frame · 15 days
estimated blood loss (in mL),
adverse maternal outcome parameters
Time frame · 15 days
incidence of PPH (in %)
adverse maternal outcome parameters
Time frame · 15 days
use of additional uterotonic agents (prostaglandines)
adverse maternal outcome parameters
Time frame · 15 days
blood transfusion (number of packed red cells)
adverse maternal outcome parameters
Time frame · 15-300 minutes
length of surgery (in minutes)
adverse maternal outcome parameters
Time frame · 15 days
number of patients with revision (second surgery in the 24hours following the primary cesarean section)
adverse maternal outcome parameters
Time frame · 15 days
admission to an intensive care unit (%)
Eligibility
Who can take part.
- Minimum age
- 18 Years
- Maximum age
- Not reported
- Sex
- FEMALE
- Healthy volunteers
- Yes
Inclusion Criteria: * elective cesarean section * present informed consent * completed 36 weeks of gestation Exclusion Criteria: * need for intubation (carbetocin is only licensed for epidural or spinal anesthesia) * multiple fetus pregnancy * known coagulopathy * Placenta praevia * morbidly adherent placenta * placental abruption * thrombocyte dysfunction * HELLP-syndrome * preeclampsia * history of uterine atony
Study locations
1 registered sites.
Switzerland. Showing up to 24 locations stored in the fast local snapshot.
University Hospital Zurich
Zurich, Switzerland
Publications
Results and literature.
No PMID-linked publications were present in this registry snapshot.
Related trials
More studies on Carbetocin.
NCT IDStudyPhase / statusEnrollmentUpdated
The Efficacy of Carbitocin in Reduction of Blood Loss During Myomectomy
Alex Ekwueme Federal University Teaching Hospital · Blood Loss, Surgical
Early Phase 1
Not yet recruiting
900
2026-07
Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority Trial
Mansoura University · Postpartum Hemorrhage · Uterine Atony
Phase 4
Not yet recruiting
332
2026-06
Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage
Sheba Medical Center · Postpartum Hemorrhage · Twin Pregnancy
Phase 4
Recruiting
120
2026-05
Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium
Samuel Lunenfeld Research Institute, Mount Sinai Hospital · Postpartum Hemorrhage
Not applicable
Recruiting
32
2026-04
Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery
Samuel Lunenfeld Research Institute, Mount Sinai Hospital · Post Partum Hemorrhage
Not applicable
Recruiting
160
2026-04
Effect of Co-administration of Carbetocin and Calcium Chloride on Uterine Tone in Patients Undergoing Elective Cesarean Delivery
Samuel Lunenfeld Research Institute, Mount Sinai Hospital · Postpartum Hemorrhage (Primary)
Not applicable
Recruiting
120
2026-04
Comparison of the Effect of Carbetocin Versus Oxytocin in the Prevention of Postpartum Hemorrhage After Emergency Caesarean Section in Antenatal Low-risk Patients
Ankara Etlik City Hospital · Postpartum Hemorrhage \(PPH\)
Not applicable
Completed
300
2026-02
Carbetocin Myocardium Trial 2014 Part 2
Oslo University Hospital · Pregnancy Complications
Phase 4
Completed
240
2026-02
Related PeptideStat pages
Put the record in context.
Research pages describe evidence. Vendor pages, where available, describe independently tracked research-product listings and are not clinical recommendations.