DRUG
Oxytocin
To be given to Oxytocin group following the clamping of the umbilical cord
Effects of Oxytocin and Carbetocin on Renal System in Cesarean Sections
Status
Unknown
Phase
Not applicable
Enrollment
100
Locations
1
Results
Not posted
Publications
2
Study summary
What the protocol is testing.
The aim of this study is to evaluate the renal outcome of patients undergoing elective C/S where oxytocin or carbetocin is used for postpartum hemorrhage prophylaxis.
Interventions
Treatment arms and agents.
DRUG
Carbetocin
To be given to Carbetocin group following the clamping of the umbilical cord
Timeline
From registration to results.
First posted
May 7, 2019
Study start
May 2019
Primary completion
Jun 2019
Study completion
Jun 2019
Results posted
Not reported
Registry updated
May 13, 2019
Outcomes
What the study measures.
Primary outcomes
Urine volume
Time frame · Intraoperative period
Total amount of intraoperative urine output in milliliters
Urinary sodium
Time frame · Preoperative, Postoperative 2nd, 4th, 24th hours
The change in urinary sodium content (milligrams) compared to the preoperative period
Blood sodium
Time frame · Preoperative, Postoperative 2nd, 4th, 24th hours
The change in blood sodium content (milligrams) compared to the preoperative period
Secondary outcomes
Blood osmolality
Time frame · Preoperative, Postoperative 2nd, 4th, 24th hours
The change in blood osmolality compared to the preoperative period
Blood loss
Time frame · Intraoperative period
The total volume of intraoperative blood loss
Need for additional uterotonics
Time frame · Starting from the preoperative period, ending at the 24th postoperative hour
Total dose (milligrams) of additional uterotonics administered
Blood transfusion
Time frame · Starting from the clamping of the umbilical cord, ending at the 24th postoperative hour
Total volume (milliliters) of blood transfused
Eligibility
Who can take part.
- Minimum age
- 18 Years
- Maximum age
- 65 Years
- Sex
- FEMALE
- Healthy volunteers
- No
Inclusion Criteria: * Term (\>37 weeks of gestation) uncomplicated pregnant women undergoing elective cesarean section Exclusion Criteria: * Patients refusing to participate in the study * Complicated pregnancies * Patients with risk factors for postpartum hemorrhage * Contraindications for oxytocin or carbetocin usage * Patients with known renal diseases * Preterm births (\<37 weeks of gestation)
Study locations
1 registered sites.
Turkey (Türkiye). Showing up to 24 locations stored in the fast local snapshot.
Ufuk University Faculty of Medicine Hospital
Ankara, Balgat, Turkey (Türkiye)
Publications
Results and literature.
PMID 23741542 ↗Larciprete G, Montagnoli C, Frigo M, Panetta V, Todde C, Zuppani B, Centonze C, Bompiani A, Malandrenis I, Cirese A, Valensise H. Carbetocin versus oxytocin in caesarean section with high risk of post-partum haemorrhage. J Prenat Med. 2013 Jan;7(1):12-8.PMID 9760035 ↗Engstrom T, Barth T, Melin P, Vilhardt H. Oxytocin receptor binding and uterotonic activity of carbetocin and its metabolites following enzymatic degradation. Eur J Pharmacol. 1998 Aug 21;355(2-3):203-10. doi: 10.1016/s0014-2999(98)00513-5.
Related trials
More studies on Carbetocin.
NCT IDStudyPhase / statusEnrollmentUpdated
The Efficacy of Carbitocin in Reduction of Blood Loss During Myomectomy
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Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-Inferiority Trial
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Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum Hemorrhage
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Recruiting
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Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo Study in Desensitized Human Myometrium
Samuel Lunenfeld Research Institute, Mount Sinai Hospital · Postpartum Hemorrhage
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Recruiting
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Comparative Efficacy of Carbetocin and Oxytocin in Parturients at Risk of Atonic Postpartum Hemorrhage Undergoing Elective Cesarean Delivery
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Not applicable
Recruiting
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Not applicable
Recruiting
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Comparison of the Effect of Carbetocin Versus Oxytocin in the Prevention of Postpartum Hemorrhage After Emergency Caesarean Section in Antenatal Low-risk Patients
Ankara Etlik City Hospital · Postpartum Hemorrhage \(PPH\)
Not applicable
Completed
300
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Carbetocin Myocardium Trial 2014 Part 2
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Phase 4
Completed
240
2026-02
Related PeptideStat pages
Put the record in context.
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