Abaloparatide Before Total Knee Arthroplasty

Change in Distal Femoral Bone Mineral Density (BMD) at the 25% Regions of Interest (ROIs)

Time frame · Baseline and approximately 18 months on study (15 months post-TKA)

Bone mineral density change at the 25% ROI of the surgical leg. Dual-energy X-ray absorptiometry (DXA) measured BMD was obtained at a point (ROI) 25% the length of the total surgical femur. Percent change at 25% ROI was calculated from baseline to 18 months.

Change in Distal Femoral BMD at the 15% and 60% ROI

Time frame · Baseline and approximately 18 months on study (15 months post-TKA)

Bone mineral density percent change at the 15% and 60% ROI of the surgical leg

TBS Assessment by TRIP at the 15%, 25%, and 60% Femur ROIs

Time frame · 18 months on study (15 months post-TKA)

Trabecular bone score (TBS) assessment by Texture Research Investigation (Platform (TRIP) software change at the 15% and 25% femur ROIs (TBS \>1.350 is normal; TBS between 1.200 and 1.350 is indicative of partially degraded microarchitecture; and TBS \<1.200 equals degraded microarchitecture).

Knee Injury & Osteoarthritis Outcome Score (KOOS) JR

Time frame · 18 months on study (15 months post-TKA)

Patient reported knee function score. The KOOS, JR was developed from the original long version of the Knee injury and Osteoarthritis Outcome Score (KOOS) survey using Rasch analysis. The KOOS, JR contains 7 items from the original KOOS survey. Items are coded from 0 to 4, none to extreme respectively. KOOS, JR is scored by summing the raw response (range 0-28) and then converting it to an interval score (0-100). The interval score ranges from 0 to 100 where 0 represents total knee disability and 100 represents perfect knee health.

Change in Veterans RAND 12 (VR-12) Question Health Survey Score: Physical Health Component

Time frame · Baseline and approximately 18 months on study (15 months post-TKA)

12 Item Health Survey using patient's self assessment of their perspective of their health and ability to do daily functions. Scores are derived using an algorithm that is referenced to a metric centered at 50.0 where a zero score indicates the lowest level of health and 100 indicates the highest level of health.

Change in Veterans RAND 12 (VR-12) Question Health Survey Score: Mental Health Component

Time frame · Baseline and approximately 18 months on study (15 months post-TKA)

12 Item Health Survey using patient's self assessment of their perspective of their health and ability to do daily functions. Scores are derived using an algorithm that is referenced to a metric centered at 50.0 where a zero score indicates the lowest level of health and 100 indicates the highest level of health.

Forgotten Joint Survey(FJS) Score

Time frame · 18 months on study (15 months post-TKA)

FJS-12 consists of 12 questions and is scored using a 5-point response format with the raw scores transformed onto a 0- to 100-point scale. High scores indicate good outcome, that is, a high degree of forgetting the joint in everyday life (forgotten joint phenomenon).

Change in Body Composition Using Bioelectrical Impedance Analysis of Lean Mass

Time frame · Baseline and approximately 18 months on study (15 months post-TKA)

Change in total body composition using bioelectrical impedance analysis of lean mass.

Change in Body Composition Using Bioelectrical Impedance Analysis of Fat Mass.

Time frame · Baseline and approximately 18 months on study (15 months post-TKA)

Change in total body composition using bioelectrical impedance analysis of fat mass.

TKA Complications: Number of Participants Needed Revision Surgery

Time frame · 18 months on study (15 months post-TKA)

TKA complications: Number of participants needed revision surgery

TKA Complications: Number of Participants Had Fracture

Time frame · 18 months on study (15 months post-TKA)

TKA complications: Number of participants had fracture