Inclusion Criteria:
* Age≥ 18 years
* Placenta previa defined by a placental edge below 20mm from internal cervical os diagnosed at the most recent transvaginal ultrasound examination before delivery, as per French guidelines
* Cesarean delivery before or during labor
* Gestational age at delivery ≥ 32 weeks + 0
* Affiliated or beneficiary to a health security system
* Signed informed consent
Exclusion Criteria:
* History of venous (deep vein thrombosis and/or pulmonary embolism) or arterial (angina pectoris, myocardial infarction, stroke) thrombotic event
* History of epilepsy or seizure
* Chronic or acute cardiovascular disease (including foramen oval, mitral stenosis, aortic stenosis, heart transplant, pulmonary hypertension); chronic or acute renal disease (including chronic or acute kidney failure with glomerular filtration rate \<90 mL/min, renal transplantation), chronic active or acute liver disorder with hemorrhagic or thrombotic risk (including cirrhosis, portal hypertension, Budd-Chiari syndrome)
* Active autoimmune disease with thromboembolic risk (including lupus, antiphospholipid syndrome, Crohn's disease)
* Sickle cell disease (homozygous)
* Severe hemostasis disorder prothrombotic (Factor V Leiden mutation - homo or heterozygous; Activated protein C (APC) resistance, Protein C deficiency, Protein S deficiency - aside from pregnancy, Homocysteinemia, , Factor 2 mutation - homo or heterozygous, Deficiency in antithrombin 3), prohemorragic (von Willebrand disease requiring desmopressin treatment during delivery, thrombocytopenia (\<30000/mm3), Glanzmann disease, hypofibrinogenemia (\<1g/L) -aside from pregnancy)
* High prenatal suspicion of placenta accreta spectrum disorder according to the obstetrician in charge
* Placenta praevia diagnosed during delivery
* Abruptio placentae
* Significant bleeding (estimated blood loss\>500ml) within 12 hours before cesarean delivery
* Eclampsia / HELLP syndrome
* In utero fetal death
* Administration of low-molecular-weight heparin or antiplatelet agents during the 7 days before delivery
* Tranexamic acid contraindication
* Sodium chloride contraindication
* Women under legal protection
* Poor understanding of the French language