Status
Completed
Phase
Not applicable
Enrollment
475
Locations
1
Results
Not posted
Publications
2
Study summary
After lung resection, troponin elevation may be regulated by mechanisms other than myocardial ischemia. Perioperative natriuretic peptides measurement may help identify changes in ventricular function during thoracic surgery. Integrating both cardiac biomarkers may improve the predictive value for cardiovascular complications after lung resection.
Objectives: To evaluate the incidence and magnitude of perioperative N-terminal pro brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin I (Tn I) elevation in patients undergoing pulmonary resection and its predictive value for cardiovascular complications. Methodology: Prospective, multicenter, observational cohort study in patients \>45 years undergoing elective thoracic surgery for lung resection. Cardiac biomarkers Tn I and NT-proBNP will be measured preoperatively and at postoperative days 1 and 2. Risk score for major cardiovascular postoperative complications will be calculated depending of both biomarkers perioperative changes.
Interventions
DIAGNOSTIC_TEST
Both biomarkers will be determined in each patient preoperatively and at postoperative day 1 and day 2.Measurements will not necessarily be taken independently of other measurements, meaning that the addition of the biomarker could be included in routine pre or postoperative day-1 and day 2 blood tests.
Timeline
First posted
Feb 11, 2021
Study start
May 19, 2021
Primary completion
Nov 30, 2023
Study completion
Jan 31, 2025
Results posted
Not reported
Registry updated
Mar 13, 2025
Outcomes
NT-proBNP perioperative changes
Time frame · Change from baseline NT-proBNP at two-days after surgery
Perioperative change in NT-Pro-Brain Natriuretic Peptide (NT-proBNP) levels in patients undergoing pulmonary resection. Cutt-of values will be NT-proBNP ≥ 300 pg/ml pg/ml
TnI perioperative changes
Time frame · Change from baseline TnI at two-days after surgery
Perioperative changes in high-sensitivity troponin I (TnI) levels in patients undergoing pulmonary resection. Cutt-of values will be TnI ≥45 ng/L
Major cardiovascular complications
Time frame · 30-days after surgery
Postoperative non-fatal cardiac arrest, acute myocardial infarction, angina, congestive heart failure, new clinically relevant cardiac arrhythmia, cardiovascular death
Not reported in the indexed record.
Eligibility
Inclusion Criteria: * Age ≥45 years old * Patients undergoing elective surgery for lung resection Exclusion Criteria: * Patients undergoing urgent, emergent, or nonthoracic surgery * Patients or family did not consent to participate * Presence of symptoms related with infection or sepsis * Patients with a documented history of severe heart failure and/or ejection fraction lower than 30%
Study locations
Spain. Showing up to 24 locations stored in the fast local snapshot.
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Publications
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