Current partner codePEPTIDESDE
NCT05757531·Phase 1·INTERVENTIONAL

A Study of Carbon-14-Labelled [14C] LY3437943 in Healthy Male Participants

Status

Completed

Phase

Phase 1

Enrollment

7

Locations

1

Results

Not posted

Publications

0

Study summary

What the protocol is testing.

The main purpose of this study is to is to look at how much LY3437943 gets into the bloodstream and how long the body takes to get rid of it in healthy male participants. This study will involve a single dose of 14C radiolabeled LY3437943. his means that a radioactive tracer substance, C14, will be incorporated into the study drug to investigate the study drug and its breakdown products and to find out how much of these pass from blood into urine, feces and expired air. The study will last up to approximately 15 weeks including the screening period of 28 days.

Interventions

Treatment arms and agents.

DRUG

[¹⁴C]-LY3437943

Administered SC.

Timeline

From registration to results.

  1. First posted

    Mar 7, 2023

  2. Study start

    Mar 17, 2023

  3. Primary completion

    Jun 23, 2023

  4. Study completion

    Jun 23, 2023

  5. Results posted

    Not reported

  6. Registry updated

    Jul 5, 2023

Outcomes

What the study measures.

Primary outcomes

Urinary Excretion of LY3437943 Radioactivity Over Time Expressed as a Percentage of the Total Radioactive Dose Administered

Time frame · Predose up to 63 days post dose

Urinary Excretion of LY3437943 Radioactivity Over Time Expressed as a Percentage of the Total Radioactive Dose Administered

Fecal Excretion of LY3437943 Radioactivity Over Time Expressed as a Percentage of the Total Radioactive Dose Administered

Time frame · Predose up to 63 days post dose

Fecal Excretion of LY3437943 Radioactivity Over Time Expressed as a Percentage of the Total Radioactive Dose Administered

Secondary outcomes

PK: Area Under the Concentration-Time Curve From Time Zero to Infinity (AUC (0-∞)) of Total Radioactivity and [¹⁴C]-LY3437943

Time frame · Predose up to 63 days post dose

PK: AUC (0-∞) of Total Radioactivity and \[¹⁴C\]-LY3437943

PK: Maximum Concentration (Cmax) of Total Radioactivity and [¹⁴C]-LY3437943

Time frame · Predose up to 63 days post dose

PK: Cmax of Total Radioactivity and \[¹⁴C\]-LY3437943

Total Radioactivity Recovered in Urine, Feces, and Expired Air (if applicable)

Time frame · Predose up to 63 days post dose

Total Radioactivity Recovered in Urine, Feces, and Expired Air (if applicable)

Total Number of Metabolites of LY3437943

Time frame · Predose up to 63 days post dose

Total Number of Metabolites of LY3437943

Eligibility

Who can take part.

Minimum age
18 Years
Maximum age
55 Years
Sex
MALE
Healthy volunteers
Yes

Inclusion Criteria: * Male participants who are overtly healthy as determined by medical evaluation * Have a body mass index within the range 18.5 to 32.0 kilograms per meter squared (kg/m²) * Have clinical laboratory test results within normal reference range for the population or investigative site, or results outside the normal reference range that are judged to be not clinically significant by the investigator. Participants with dyslipidemia may be included in the study, at the discretion of the investigator, as long as they fulfill other eligibility criteria * Have venous access sufficient to allow for blood sampling as per the protocol * Are willing to receive study treatment by SC injections * Have a history of a minimum of 1 bowel movement per day * Contraceptive use by participants should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. Exclusion Criteria: * Have a clinically significant abnormal blood pressure and/or pulse rate as determined by the investigator at screening or check-in * Have significant history of or current cardiovascular, respiratory, hepatic, renal, GI, endocrine, hematological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; of constituting a risk when taking the IP; or of interfering with the interpretation of data * Have evidence of significant active neuropsychiatric disease, as determined by the investigator * Show evidence of HIV infection and/or positive HIV antibodies, hepatitis C and/or positive hepatitis C antibody, hepatitis B and/or positive hepatitis B surface antigen * Have a history of constipation or have had acute constipation within 3 weeks prior to check-in * Have evidence of active renal disease (eg, diabetic renal disease, polycystic kidney disease) or an estimated creatinine clearance of less than 70 mL/minute, calculated using the Chronic Kidney Disease-Epidemiology equation * Have a history or presence of pancreatitis (history of chronic pancreatitis or idiopathic acute pancreatitis) and/or elevation in serum amylase or lipase (greater than 1.5-fold the ULN) at screening * Have used or plan to use over-the-counter or prescription medication, and/or dietary or herbal supplements (with the exception of vitamin supplements, acetaminophen and/or thyroid replacement therapy) within 14 days or 5 half-lives (whichever is longer) prior to dosing and for the duration of the study, including any medications that reduce GI motility, including, but not limited to, anticholinergics, antispasmodics, 5 hydroxytryptamine-3 receptor antagonists, dopamine antagonists, and opiates * Have had exposure to significant radiation within 12 months prior to dosing (eg, serial x-ray or CT scans, barium meal, being employed in a job requiring radiation exposure monitoring) * Have participated in any clinical trial involving a radiolabeled substance within the past 12 months

Study locations

1 registered sites.

United States. Showing up to 24 locations stored in the fast local snapshot.

Covance Clinical Research Unit

Madison, Wisconsin, United States

Publications

Results and literature.

No PMID-linked publications were present in this registry snapshot.

Primary links

Continue at the source.

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Put the record in context.

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