DRUG
Retatrutide
Administered subcutaneously (SC)
Status
Completed
Phase
Phase 1
Enrollment
30
Locations
1
Results
Not posted
Publications
0
Study summary
The purpose of this study J1I-MC-GZQE is to measure the effect of retatrutide on the pharmacokinetics (PK) of metoprolol in healthy participants.
Interventions
DRUG
Administered subcutaneously (SC)
DRUG
Administered orally
Timeline
First posted
Feb 5, 2025
Study start
Feb 3, 2025
Primary completion
Apr 15, 2025
Study completion
Apr 15, 2025
Results posted
Not reported
Registry updated
Jun 5, 2025
Outcomes
Pharmacokinetics (PK): Area Under Concentration From Time Zero to Infinity (AUC[0-∞]) of Metoprolol
Time frame · Day 1 to Day 3
PK: AUC (0-∞) of Metoprolol
Pharmacokinetics (PK): AUC (0-∞) of Metoprolol with Retatrutide
Time frame · Day 9 to Day 11
PK: AUC (0-∞) of Metoprolol with Retatrutide
PK: Maximum Concentration (Cmax) of Metoprolol
Time frame · Day 1 to Day 3
PK: Cmax of Metoprolol
PK: Cmax of Metoprolol with Retatrutide
Time frame · Day 9 to Day 11
PK: Cmax of Metoprolol with Retatrutide
Number of Participants with an Incidence of Treatment Emergent Adverse Events TEAEs (TEAEs)
Time frame · Baseline to Day 44
Eligibility
Inclusion Criteria: * Are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and vital signs * Have a body mass index (BMI) within the range 22.0 to 35.0 kilogram per square meter (kg/m2) (inclusive) at screening Exclusion Criteria: * Have history of diabetes (except gestational diabetes) or current diagnosis of diabetes (any form), or have glycated hemoglobin (HbA1c) greater than or equal to (≥) 6.5% (48 millimole/mole (mmol/mol) * Have a mean supine screening pulse rate of less than 45 or greater than 100 beats per minute (bpm) from 2 assessments. If a repeat measurement (mean of 2 assessments) shows values within the range of 45 to 100 bpm, the participant may be included in the trial * Have significant history of or current cardiovascular, respiratory, hepatic, renal, GI, endocrine, hematological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; of constituting a risk when taking the study drug; or of interfering with the interpretation of data * Had any of the following cardiovascular conditions prior to screening: acute myocardial infarction, cerebrovascular accident, unstable angina, or hospitalization due to congestive heart failure
Study locations
Singapore. Showing up to 24 locations stored in the fast local snapshot.
Lilly Centre for Clinical Pharmacology
Singapore, Singapore
Publications
No PMID-linked publications were present in this registry snapshot.
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