Current partner codePEPTIDESDE
NCT06808802·Phase 1·INTERVENTIONAL

To Investigate the Effect of Retatrutide (LY3437943) on Metoprolol Pharmacokinetics in Healthy Participants

Status

Completed

Phase

Phase 1

Enrollment

30

Locations

1

Results

Not posted

Publications

0

Study summary

What the protocol is testing.

The purpose of this study J1I-MC-GZQE is to measure the effect of retatrutide on the pharmacokinetics (PK) of metoprolol in healthy participants.

Interventions

Treatment arms and agents.

DRUG

Retatrutide

Administered subcutaneously (SC)

DRUG

Metoprolol

Administered orally

Timeline

From registration to results.

  1. First posted

    Feb 5, 2025

  2. Study start

    Feb 3, 2025

  3. Primary completion

    Apr 15, 2025

  4. Study completion

    Apr 15, 2025

  5. Results posted

    Not reported

  6. Registry updated

    Jun 5, 2025

Outcomes

What the study measures.

Primary outcomes

Pharmacokinetics (PK): Area Under Concentration From Time Zero to Infinity (AUC[0-∞]) of Metoprolol

Time frame · Day 1 to Day 3

PK: AUC (0-∞) of Metoprolol

Pharmacokinetics (PK): AUC (0-∞) of Metoprolol with Retatrutide

Time frame · Day 9 to Day 11

PK: AUC (0-∞) of Metoprolol with Retatrutide

PK: Maximum Concentration (Cmax) of Metoprolol

Time frame · Day 1 to Day 3

PK: Cmax of Metoprolol

PK: Cmax of Metoprolol with Retatrutide

Time frame · Day 9 to Day 11

PK: Cmax of Metoprolol with Retatrutide

Secondary outcomes

Number of Participants with an Incidence of Treatment Emergent Adverse Events TEAEs (TEAEs)

Time frame · Baseline to Day 44

Eligibility

Who can take part.

Minimum age
21 Years
Maximum age
65 Years
Sex
ALL
Healthy volunteers
Yes

Inclusion Criteria: * Are overtly healthy as determined by medical evaluation including medical history, physical examination, laboratory tests, and vital signs * Have a body mass index (BMI) within the range 22.0 to 35.0 kilogram per square meter (kg/m2) (inclusive) at screening Exclusion Criteria: * Have history of diabetes (except gestational diabetes) or current diagnosis of diabetes (any form), or have glycated hemoglobin (HbA1c) greater than or equal to (≥) 6.5% (48 millimole/mole (mmol/mol) * Have a mean supine screening pulse rate of less than 45 or greater than 100 beats per minute (bpm) from 2 assessments. If a repeat measurement (mean of 2 assessments) shows values within the range of 45 to 100 bpm, the participant may be included in the trial * Have significant history of or current cardiovascular, respiratory, hepatic, renal, GI, endocrine, hematological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; of constituting a risk when taking the study drug; or of interfering with the interpretation of data * Had any of the following cardiovascular conditions prior to screening: acute myocardial infarction, cerebrovascular accident, unstable angina, or hospitalization due to congestive heart failure

Study locations

1 registered sites.

Singapore. Showing up to 24 locations stored in the fast local snapshot.

Lilly Centre for Clinical Pharmacology

Singapore, Singapore

Publications

Results and literature.

No PMID-linked publications were present in this registry snapshot.

Primary links

Continue at the source.

Related trials

More studies on Retatrutide.

Related PeptideStat pages

Put the record in context.

Research pages describe evidence. Vendor pages, where available, describe independently tracked research-product listings and are not clinical recommendations.