Bivalirudin with Prolonged Infusion During PCI Versus Heparin After Fibrinolytic Therapy

Inclusion Criteria: * Any age * STEMI patients received fibrinolysis therapy within 12h of symptom onset and are planned to undergo PCI within 24h of symptom onset. * Dual antiplatelet drugs must be administrated according to guidelines before PCI (loading doses and maintenance doses of aspirin and clopidogrel or ticagrelor) * Patients requiring staged revascularization of non-culprit vessels within 30 days may be enrolled. In such cases the same antithrombotic agents and PCI procedures must be used in the staged procedure consistent with the index procedure PCI, in particular the assigned antithrombin agent heparin vs. bivalirudin); * The subject or legal representative has been informed of the nature of the study, understood the provisions of the protocol, was able to ensure adherence, and signed informed consent. Exclusion Criteria: * Not suitable for PCI; * Mechanical complications (such as ventricular septal rupture, papillary muscle rupture with acute mitral regurgitation, etc.); * Cardiogenic shock(Killip IV) * Known allergy or contraindications to heparin, bivalirudin, aspirin, or both clopidogrel and ticagrelor * Patients who underwent PCI in past 30 days * Patients in whom the investigators consider inappropriate to participate in this study (eg, have participated in another drug/instrument study or undergoing another drug/instrument study, pregnancy).