Current partner codePEPTIDESDE
NCT07401862·Phase 1·INTERVENTIONAL

A Study of Eloralintide (LY3841136) in Participants With Different Levels of Liver Damage and in Participants With Healthy Livers.

Status

Recruiting

Phase

Phase 1

Enrollment

36

Locations

3

Results

Not posted

Publications

0

Study summary

What the protocol is testing.

The main purpose of this study is to evaluate how a medicine, LY3841136, works in participants with different levels of liver damage and in participants with healthy liver. The researchers want to see how the medicine is absorbed and used by the body, and if it causes any side effects, in participants with mild, moderate, or severe liver damage, as well as in participants with normal liver function. For each participant, the study will last about 14 weeks, which will include a stay at the clinical research unit for 5 nights.

Interventions

Treatment arms and agents.

DRUG

LY3841136

Administered SC

Timeline

From registration to results.

  1. First posted

    Feb 11, 2026

  2. Study start

    Feb 10, 2026

  3. Primary completion

    Mar 2027

  4. Study completion

    Mar 2027

  5. Results posted

    Not reported

  6. Registry updated

    Jun 4, 2026

Outcomes

What the study measures.

Primary outcomes

Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve From Zero to Infinity AUC(0-∞) of LY3841136

Time frame · Predose on Day 1 up to Day 71

PK: Maximum Observed Drug Concentration (Cmax) of LY3841136

Time frame · Predose on Day 1 up to Day 71

Secondary outcomes

Not reported in the indexed record.

Eligibility

Who can take part.

Minimum age
18 Years
Maximum age
85 Years
Sex
ALL
Healthy volunteers
Yes

Inclusion Criteria: * Have a body weight of 55 kilograms (kg) or more and body mass index between 19.0 and 40.0 kilograms per square meter (kg/m²), inclusive Group 1 * Are healthy as determined by medical history, physical examination, and other screening procedures, with clinically normal hepatic function at screening Groups 2 through 4 * Have hepatic impairment classified as Child-Pugh score A, B, or C (mild, moderate, or severe impairment who are considered acceptable for participation in this study by the investigator. Participants must have a diagnosis of chronic hepatic impairment of greater than 6 months per physician diagnosis and standard-of-care practice, with no clinically significant changes in the opinion of the investigator within 15 days prior to screening Participants with hepatic impairment may have stable baseline medical conditions for which neither the condition nor treatments received would negatively impact the health of the participant or study conduct Exclusion Criteria: * Have a history or presence of chronic or acute pancreatitis or elevation in serum amylase or lipase greater than 1.5 × upper limit of normal (ULN) * Are pregnant or intend to become pregnant or to breastfeed during the study Group 1 * Have liver disease, obvious clinical signs or symptoms of liver disease, acute or chronic hepatitis, or have elevations in aspartate aminotransferase (AST) or alanine transaminase (ALT) greater than 1.5 × ULN or total bilirubin (TBL) greater than 1.5 × ULN at screening * Have a current infection with hepatitis B virus (HBV), that is, * if hepatitis B surface antigen (HBsAg) is positive, the participant is excluded, or * if HBsAg is negative and anti-Hepatitis B core antibody (HBc) is positive, further testing for HBV deoxyribonucleic acid (DNA) is required, and * if the screening HBV DNA is positive, the participant is excluded * Have a current infection with hepatitis C virus (HCV), that is, * if anti-HCV is positive, a test for circulating HCV ribonucleic acid (RNA) is required, and * if HCV RNA test is positive, the participant is excluded Groups 2, 3, and 4 * Have presence of active portal shunt or transjugular intrahepatic portosystemic shunt * Require paracentesis more often than 2 times per month or are expected to require paracentesis during the study * Have evidence of spontaneous bacterial peritonitis within 6 months of screening * Have had variceal bleeding within 3 months of screening. If the participant has undergone a successful banding procedure, they may participate in the study providing at least 1 month has passed after the banding procedure at the time of screening * Show presence of hepatocellular carcinoma * Have hepatic encephalopathy of Grade 2 or higher * Have TBL greater than 15 milligrams per deciliter (mg/dL) * Have ALT greater than or equal to 6 × ULN

Study locations

3 registered sites.

Hungary · United States. Showing up to 24 locations stored in the fast local snapshot.

Orlando Clinical Research Center

Orlando, Florida, United States

American Research Corporation

San Antonio, Texas, United States

CRU Early Phase Unit

Kistarcsa, Hungary

Publications

Results and literature.

No PMID-linked publications were present in this registry snapshot.

Primary links

Continue at the source.

Related trials

More studies on Eloralintide.

Related PeptideStat pages

Put the record in context.

Research pages describe evidence. Vendor pages, where available, describe independently tracked research-product listings and are not clinical recommendations.