DRUG
LY3841136
Administered SC
Status
Recruiting
Phase
Phase 1
Enrollment
28
Locations
2
Results
Not posted
Publications
0
Study summary
The purpose of the study is to assess the amount of Eloralintide (LY3841136) that reaches the bloodstream and the time it takes for the body to get rid of it when given to participants with renal (kidney) impairment and to healthy participants. The study drug will be administered subcutaneously (SC) (under the skin). For each participant, the study will last about 14 weeks, excluding screening.
Interventions
DRUG
Administered SC
Timeline
First posted
Feb 23, 2026
Study start
Feb 24, 2026
Primary completion
Oct 2026
Study completion
Oct 2026
Results posted
Not reported
Registry updated
Mar 13, 2026
Outcomes
Pharmacokinetics (PK): Area Under the Concentration Versus Time Curve From Zero to Infinity AUC(0-∞) of LY3841136
Time frame · Predose on Day 1 up to Day 71
PK: Maximum Observed Drug Concentration (Cmax) of LY3841136
Time frame · Predose on Day 1 up to Day 71
Not reported in the indexed record.
Eligibility
Inclusion Criteria: * Have a body weight of 55 kilograms (kg) or more and a body mass index (BMI) within the range of 19.0 to 40.0 kilograms per square meter (kg/m²), inclusive * Have no significant history of spontaneous or ethanol-induced hypoglycemia Additional Inclusion Criteria for Group 1 * Are healthy as determined by medical history, physical examination, and other screening procedures, with normal renal function, assessed by estimated glomerular filtration rate (eGFR) of at least 90 milliliters per minute (mL/min) * Have glycated hemoglobin (HbA1c) less than or equal to 6.5% at screening Additional Inclusion Criteria for Groups 2 and 3 * Have stable severe renal impairment, assessed by eGFR less than 30 mL/min at screening or with end-stage renal disease (ESRD) who have been on a stable hemodialysis (HD) schedule for at least 3 months prior to planned dosing * Have acceptable blood pressure and pulse rate * If participants have Type 2 Diabetes Mellitus (T2DM), they must have a HbA1c equal to or less than 10.0% at screening Exclusion Criteria: * Have a history of chronic liver disease, acute or chronic hepatitis, including a history of autoimmune hepatitis, any evidence for hepatic impairments * Have a current, functioning organ transplant. Nonfunctional renal allografts may be considered * Have significant history or current cardiovascular, respiratory, hepatic, renal, gastrointestinal (GI), endocrine, hematological, dermatological, or neurological disorders capable of significantly altering the absorption, metabolism, or elimination of drugs; constituting a risk when taking the investigational product; or interfering with the interpretation of data Groups 2 and 3 * Are receiving continuous HD or peritoneal dialysis. * Have used any drug indicated for medical care of the participant's renal impairment, which is not established in dose and administered for at least 7 days before eloralintide administration
Study locations
United States. Showing up to 24 locations stored in the fast local snapshot.
Floridian Clinical Research, LLC
Miami Lakes, Florida, United States
Omega Research Orlando LLC
Orlando, Florida, United States
Publications
No PMID-linked publications were present in this registry snapshot.
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