A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Relative change in body weight

Time frame · From baseline (week 0) to (week 80)

Measured as percentage (%) of body weight.

Change in WOMAC Osteoarthritis Index NRS 3.1 (24-hour) (WOMAC) pain score

Time frame · From baseline (week 0) to (week 80)

Measured as score on a scale. Western Ontario and McMaster Universities Arthritis Index (WOMAC) measures symptoms in the areas of pain, stiffness, and physical function. The measure consists of 24 items yielding 3 subscale scores and 1 total score. WOMAC raw scores are transformed to a standardised 0 to 100 score range. Higher scores indicate worse pain, stiffness, physical function, and overall osteoarthritis- related disability.

Change in WOMAC physical function score

Time frame · From baseline (week 0) to (week 80)

Measured as score on a scale. Physical function score will be calculated according to the guidelines provided in the WOMAC User Guide XI. Score ranges from 0-100 and higher scores indicate worse physical function.

Change in SF-36v2® Health Survey Acute (SF-36v2 Acute) physical functioning score

Time frame · From baseline (week 0) to (week 80)

Measured as score on a scale. SF-36v2 Acute measures Health-Related Quality of Life (HRQOL). The measure consists of 36 items yielding 8 health domain scores and 2 component summary scores. SF-36v2 Acute scores are norm-based scores, that is transformed to a scale where the 2009 US general population has a mean of 50 and a standard deviation (SD) of 10. Higher scores indicate better functional health and well-being. The physical functioning ranges from 19.0 to 57.6.

Change in body weight

Time frame · From baseline (week 0) to (week 80)

Measured as kilogram (kg).

Change in body mass index (BMI)

Time frame · From baseline (week 0) to (week 80)

Measured as kilograms per meter squared (kg/m\^2).

Change in WOMAC stiffness score

Time frame · From baseline (week 0) to (week 80)

Measured as score on a scale. Stiffness score will be calculated according to the guidelines provided in the WOMAC User Guide XI. Score ranges from 0-100 and higher scores indicate worse stiffness.

Change in WOMAC total score

Time frame · From baseline (week 0) to (week 80)

Measured as score on a scale. Total score will be calculated according to the guidelines provided in the WOMAC User Guide XI. Total score ranges from 0-100 and higher scores indicate worse overall osteoarthritis- related disability.

Change in waist circumference

Time frame · From baseline (week 0) to (week 80)

Measured as centimetre (cm).

Change in systolic blood pressure (SBP)

Time frame · From baseline (week 0) to (week 80)

Measured as millimetre of mercury (mmHg).

Change in diastolic blood pressure (DBP)

Time frame · From baseline (week 0) to (week 80)

Measured as mmHg.

Change in total cholesterol

Time frame · From baseline (week 0) to (week 80)

Measured as ratio to baseline.