AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee Osteoarthritis Lose Weight and Reduce Pain

Relative change in body weight

Time frame · From baseline (week 0) to week 80

Measured as percentage change in body weight.

Change in Western Ontario and McMaster Universities Osteoarthritis Index Numerical Rating Scale (NRS) 3.1 (24-hour) (WOMAC) pain score

Time frame · From baseline (week 0) to week 80

WOMAC is a participant reported outcome (PRO) measures symptoms in the areas of pain, stiffness, and physical function in participants with osteoarthritis of the hip and/or knee. The measure consists of 24 items yielding 3 subscale scores and 1 total score. WOMAC raw scores are transformed to a standardised 0 to 100 score range. Higher scores indicate worse pain, stiffness, physical function, and overall osteoarthritis-related disability. Subscale score for pain ranges 0-100, where higher score indicates worse pain. Measured as score on a scale.

Change in WOMAC physical function score

Time frame · From baseline (week 0) to week 80

WOMAC is a PRO measures symptoms in the areas of pain, stiffness, and physical function in participants with osteoarthritis of the hip and/or knee. The measure consists of 24 items yielding 3 subscale scores and 1 total score. WOMAC raw scores are transformed to a standardised 0 to 100 score range. Higher scores indicate worse pain, stiffness, physical function, and overall osteoarthritis-related disability. Subscale score for physical function ranges 0-100, where higher score indicates worse physical function. Measured as score on a scale.

Change in SF-36v2® Health Survey Acute (SF-36v2 Acute) physical functioning score

Time frame · From baseline (week 0) to week 80

SF-36v2 Acute measures Health-Related Quality of Life (HRQOL). The measure consists of 36 items yielding 8 health domain scores and 2 component summary scores. SF-36v2 Acute scores are norm-based scores, i.e. transformed to a scale where the 2009 US general population has a mean of 50 and a standard deviation (SD) of 10. Higher scores indicate better functional health and well-being. The physical functioning ranges from 19.0 to 57.6. Measured as score on a scale.

Change in body weight

Time frame · From baseline (week 0) to week 80

Measured as kilograms (kg).

Change in body mass index (BMI)

Time frame · From baseline (week 0) to week 80

Measured as kilograms per meter squared (kg/m\^2).

Change in WOMAC stiffness score

Time frame · From baseline (week 0) to week 80

WOMAC is a PRO measures symptoms in the areas of pain, stiffness, and physical function in participants with osteoarthritis of the hip and/or knee. The measure consists of 24 items yielding 3 subscale scores and 1 total score. WOMAC raw scores are transformed to a standardised 0 to 100 score range. Higher scores indicate worse pain, stiffness, physical function, and overall osteoarthritis-related disability. Subscale score for stiffness ranges 0-100, where higher score indicates worse stiffness. Measured as score on a scale.

Change in WOMAC total score

Time frame · From baseline (week 0) to week 80

WOMAC is a PRO measures symptoms in the areas of pain, stiffness, and physical function in participants with osteoarthritis of the hip and/or knee. The measure consists of 24 items yielding 3 subscale scores and 1 total score. WOMAC raw scores are transformed to a standardised 0 to 100 score range. Higher scores indicate worse pain, stiffness, physical function, and overall osteoarthritis-related disability. Total score ranges 0-100, where higher score indicates worse pain, stiffness, physical function and overall osteoarthritis related disability. Measured as score on a scale.

Change in waist circumference

Time frame · From baseline (week 0) to week 80

Measured as centimetres (cm).

Change in systolic blood pressure (SBP)

Time frame · From baseline (week 0) to week 80

Measured as millimetre of mercury (mmHg).

Change in diastolic blood pressure (DBP)

Time frame · From baseline (week 0) to week 80

Measured as mmHg.

Ratio to baseline: change in total cholesterol

Time frame · From baseline (week 0) to week 80

Measured as ratio.