OTHER
No Intervention: Observational Cohort
no intervention
Neural Respiratory Drive Combined With Pro-Brain Natriuretic Peptide (Pro-BNP) as Predictor of Deterioration After Lung Transplantation
Status
Completed
Phase
Not applicable
Enrollment
80
Locations
1
Results
Not posted
Publications
0
Study summary
What the protocol is testing.
Lung transplantation has become a promising therapeutic option for various end-stage lung diseases. However, many factors such as infection, graft rejection, airway complications would cause deterioration and shorten the survival time. It is important to detect the deterioration early and receive treatment timely, which may enhance survival. We hypothesis the decreased neural respiratory drive(NRD) would be increased in the deterioration due to the aggravation of lung. Furthermore, pro-Brain Natriuretic Peptide(pro-BNP) has been reported to be associated with greater mortality after lung transplantation.For this reason, we investigated the NRD and pro-BNP before and after lung transplantation and during deterioration. 80 patients were recruited.They were end-stage lung disease patients admitted to hospital for lung transplantation. The NRD and pro-BNP were monitored before and after lung transplantation.we investigated the NRD and pro-BNP before and after lung transplantation and during deterioration.
Interventions
Treatment arms and agents.
Timeline
From registration to results.
First posted
Apr 13, 2026
Study start
Jan 1, 2016
Primary completion
Feb 1, 2026
Study completion
Feb 1, 2026
Results posted
Not reported
Registry updated
Apr 13, 2026
Outcomes
What the study measures.
Primary outcomes
deterioration
Time frame · 6 years
deterioration rate
Secondary outcomes
Not reported in the indexed record.
Eligibility
Who can take part.
- Minimum age
- 20 Years
- Maximum age
- 85 Years
- Sex
- ALL
- Healthy volunteers
- No
Inclusion Criteria: The patients with end-stage lung diseases referral to lung transplantation,Including chronic obstructive pulmonary disease, interstitial lung disease, bronchiectasia Exclusion Criteria: (1) Malignancy （2）Severe cardiovascular diseases （3）Neuromuscular and chest wall deformity (4) Cardiovascular instability (hypotension, arrhythmias, myocardial infarction) (5) Change in mental status; uncooperative patients （6）Renal failure and severe blood electrolyte disturbances
Study locations
1 registered sites.
China. Showing up to 24 locations stored in the fast local snapshot.
Facility not named
Guangzhou, China
Publications
Results and literature.
No PMID-linked publications were present in this registry snapshot.
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Related PeptideStat pages
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