A Research Study Looking Into How Cagrilintide Influences Food Intake and Appetite in People With Overweight or Obesity

Relative change in total energy intake across ad libitum breakfast, lunch, evening meal and snack box

Time frame · From baseline (Day 2) to end of treatment (Day 127)

Measured in percentage (%).

Change in total energy intake across ad libitum breakfast, lunch, evening meal and snack box

Time frame · From baseline (Day 2) to end of treatment (Day 127)

Measured in kilojoule (kJ).

Change in total amount of food consumed across ad libitum breakfast, lunch, evening meal and snack box

Time frame · From baseline (Day 2) to end of treatment (Day 127)

Measured in grams (g).

Absolute change in energy intake of high fat + sweet, high fat + non-sweet, low fat + sweet, low fat + non sweet in the evening snack box

Time frame · From baseline (Day 2) to end of treatment (Day 127)

Measured in kJ.

Change in mean postprandial appetite score (AS) based on Visual Analogue Scale (VAS)

Time frame · From baseline (Day 1) to end of treatment (Day 126)

Measured in millimetre(mm). VAS appetite questions record the participants' sensations within Hunger, Satiety, Fullness and Prospective food consumption by the participants on a paper printed scale line from 0 to 100 mm. The appetite score will be calculated as \[hunger + (100 - satiety) + (100 - fullness) + prospective food consumption\]/4. Scores of 0 mm are worst and scores of 100 mm are best.

Change in mean postprandial VAS ratings of: hunger, fullness, satiety and prospective food consumption

Time frame · From baseline (Day 1) to end of treatment (Day 126)

Measured in mm. VAS appetite questions record the participants' sensations within Hunger, Satiety, Fullness and Prospective food consumption by the participants on a paper printed scale line from 0 to 100 mm. The appetite score will be calculated as \[hunger + (100 - satiety) + (100 - fullness) + prospective food consumption\]/4. Scores of 0 mm are worst and scores of 100 mm are best.

Change in mean postprandial VAS ratings of: visual appearance, taste and overall pleasantness

Time frame · From baseline (Day 1) to end of treatment (Day 126)

Measured in mm. VAS appeal questions record the participant's sensations within taste, visual appearance and overall pleasantness by the participants on a paper printed scale line from 0 to 100 mm. Scores of 0 mm are worst and scores of 100 mm are best.

Change in fasting VAS appetite ratings of: Hunger, fullness, satiety, prospective food consumption and AS

Time frame · From baseline (Day 1) to end of treatment (Day 126)

Measured in mm. VAS appetite questions record the participant's sensations within Hunger, Satiety, Fullness and Prospective food consumption by the participants on a paper printed scale line from 0 to 100 mm. The appetite score will be calculated as \[hunger + (100 - satiety) + (100 - fullness) + prospective food consumption\]/4. Scores of 0 mm are worst and scores of 100 mm are best.

• Change in mean Control of Eating questionnaire (CoEQ), domain: Craving Control score, positive mood score, craving for sweets score, craving for Savory food score

Time frame · From baseline (Day -1) to end of treatment (Day 125)

Measured in score points. The COEQ is a self-reported measure assessing various aspects of eating behaviour and related psychological factors. The COEQ has 19 different questions designed to assess the intensity and type of food cravings, as well as subjective sensations of appetite and mood. The total score for each subscale is calculated as the sum of the item scores divided by the number of items in the subscale. Scores ranges are thus: Craving Control (0-50/5 = 0-10); Positive Mood (0-40/4 = 0-10); Craving Sweet (0-40/4 = 0-10); Craving Savoury food (0-40/4 = 0-10); Higher score represents a greater level of Craving Control.

Change in mean Power of Food questionnaire for: food available score, food present score, food tasted score, composite score

Time frame · From baseline (Day -1) to end of treatment (Day 125)

Measured in score points. The power of food questionnaire measures three factors that correspond to different levels of food proximity and reflect responsiveness to food-abundant environments: food available (food that is available, but not physically present), food present (food that is present, but not tasted), and food tasted (food that is tasted, but not consumed). Moreover, an aggregate score is calculated as the mean of the three subdomains. The questionnaire consists of 15 questions, and the participants will be asked to rate their agreement or disagreement with each statement on a 5-point scale (ranging from "strongly disagree" to "strongly agree").