DRUG
Cagrilintide
Cagrilintide will be administered subcutaneously.
Status
Recruiting
Phase
Phase 1
Enrollment
114
Locations
11
Results
Not posted
Publications
0
Study summary
The purpose of this clinical study is to look at the safety of the medicine Cagrilintide when compared to placebo in people who do not tolerate marketed glucagon-like peptide-1 (GLP-1) therapies and who live with overweight or obesity. Participants will get either Cagrilintide (the treatment being tested) or Placebo (a treatment that has no active medicine in it). Which treatment participant will get is decided by chance. The study will last for about 8 months.
Interventions
DRUG
Cagrilintide will be administered subcutaneously.
DRUG
Placebo matched to Cagrilintide will be administered subcutaneously.
Timeline
First posted
May 26, 2026
Study start
May 29, 2026
Primary completion
Nov 19, 2027
Study completion
Nov 19, 2027
Results posted
Not reported
Registry updated
Jun 25, 2026
Outcomes
Percentage of participants on standard dose or higher dose (yes/no) of cagrilintide and placebo
Time frame · At week 26
Measured as percentage of participants.
Not reported in the indexed record.
Eligibility
Key Inclusion Criteria: * Male or female (sex at birth) * Age 18 years or above at the time of signing the informed consent * History of documented treatment with GLP-1-RA medications with gastrointestinal (GI) adverse effects as the main reason for treatment discontinuation * Not suitable for re-initiation of GLP-1-RA treatment based on medical history and investigator judgement * Body mass index (BMI) greater than or equal to (≥) 30.0 kilograms per square meter (kg/m\^2) Key Exclusion Criteria: * Female who is pregnant, breast-feeding, or intends to become pregnant or is of childbearing potential and not using highly effective contraceptive methods * Treatment with GLP-1 receptor agonist or GLP-1-RA medication for any indication within 8 weeks before screening * History of type 1 or type 2 diabetes * Glycated haemoglobin (HbA1c) ≥ 6.5 percent (%) (48 millimole per mole \[mmol/mol\]) as measured by the central laboratory at screening * Treatment with glucose-lowering agent(s) prescribed for the indication of diabetes or pre-diabetes within 90 days before screening * Treatment with any medication prescribed for the indication of weight management within 8 weeks before screening
Study locations
United States. Showing up to 24 locations stored in the fast local snapshot.
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
Northeast Research Institute
Fleming Island, Florida, United States
Jacksonville Ctr For Clin Res
Jacksonville, Florida, United States
Center for Diab,Obes & Metab
Pembroke Pines, Florida, United States
Encore Medical Research of Weston
Weston, Florida, United States
Monroe Biomedical Research, LLC
Monroe, North Carolina, United States
Accellacare
Wilmington, North Carolina, United States
Coastal Carolina Research Ctr
North Charleston, South Carolina, United States
Holston Medical Group_Bristol
Bristol, Tennessee, United States
Amarillo Medical Specialists
Amarillo, Texas, United States
Elligo Clin Res Centre
Austin, Texas, United States
Publications
No PMID-linked publications were present in this registry snapshot.
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