DRUG
Eloralintide
Eloralintide administered SC
Status
Recruiting
Phase
Phase 1
Enrollment
115
Locations
2
Results
Not posted
Publications
0
Study summary
The main purpose of the study is to measure and compare the effects of eloralintide and placebo on insulin sensitivity (how your body responds to insulin), metabolic health (things like sugar and cholesterol), and body weight in participants with obesity or overweight. For each participant, the study will last about 35 weeks and include 3 in patient visits totaling 7 days.
Interventions
DRUG
Eloralintide administered SC
OTHER
Placebo administered SC
Timeline
First posted
Jun 24, 2026
Study start
Jun 24, 2026
Primary completion
Aug 2027
Study completion
Aug 2027
Results posted
Not reported
Registry updated
Jul 16, 2026
Outcomes
Change From Baseline In Hyperinsulinemic Euglycemic Clamp (HEC) Predicted Clamp-Derived Insulin Sensitivity (M-value)
Time frame · Baseline, Week 24
Change From Baseline In Body Weight
Time frame · Baseline, Week 24
Eligibility
Inclusion Criteria: * Have an hemoglobin A1c (HbA1c) value at screening of less than 6.5 percent (%). * Have a body mass index between 25 and 45 Kilogram per Square Meter (kg/m²). * Have had a stable body weight that has changed by less than 5% during the 3 months prior to screening. * Are individuals assigned male at birth (AMAB) or assigned female at birth (AFAB). Individuals of childbearing potential (IOCBP) and individuals not of childbearing potential (INOCBP) may participate in this study. Exclusion Criteria: * Have type 1 or type 2 diabetes mellitus, a history of ketoacidosis, or of hyperosmolar state or coma. Note: Participants with a history of gestational diabetes are eligible to participate in this study. * Have acute or chronic pancreatitis or a history of acute idiopathic pancreatitis. * Have a known clinically significant gastric emptying abnormality or chronically take drugs that directly affect gastrointestinal (GI) motility to a significant extent. * Have a prior or planned surgical treatment for obesity. Exceptions: The following are allowed if they occurred more than 1 year before screening: * liposuction * cryolipolysis, or * abdominoplasty. * Are unwilling to comply with the lifestyle and dietary restrictions required for this study. * Are individuals AFAB who are lactating. * Are individuals AFAB who are pregnant or intend to become pregnant or to breastfeed during the study, or individuals AMAB who intend to conceive a pregnancy during the study.
Study locations
Germany · Sweden. Showing up to 24 locations stored in the fast local snapshot.
Profil Institut für Stoffwechselforschung
Neuss, Germany
CTC GoCo
Mölndal, Sweden
Publications
No PMID-linked publications were present in this registry snapshot.
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