Current partner codePEPTIDESDE
NCT07665879·Phase 1·INTERVENTIONAL

A Study of Eloralintide (LY3841136) in Participants With Overweight or Obesity

Status

Recruiting

Phase

Phase 1

Enrollment

115

Locations

2

Results

Not posted

Publications

0

Study summary

What the protocol is testing.

The main purpose of the study is to measure and compare the effects of eloralintide and placebo on insulin sensitivity (how your body responds to insulin), metabolic health (things like sugar and cholesterol), and body weight in participants with obesity or overweight. For each participant, the study will last about 35 weeks and include 3 in patient visits totaling 7 days.

Interventions

Treatment arms and agents.

DRUG

Eloralintide

Eloralintide administered SC

OTHER

Placebo

Placebo administered SC

Timeline

From registration to results.

  1. First posted

    Jun 24, 2026

  2. Study start

    Jun 24, 2026

  3. Primary completion

    Aug 2027

  4. Study completion

    Aug 2027

  5. Results posted

    Not reported

  6. Registry updated

    Jul 16, 2026

Outcomes

What the study measures.

Primary outcomes

Change From Baseline In Hyperinsulinemic Euglycemic Clamp (HEC) Predicted Clamp-Derived Insulin Sensitivity (M-value)

Time frame · Baseline, Week 24

Secondary outcomes

Change From Baseline In Body Weight

Time frame · Baseline, Week 24

Eligibility

Who can take part.

Minimum age
18 Years
Maximum age
70 Years
Sex
ALL
Healthy volunteers
Yes

Inclusion Criteria: * Have an hemoglobin A1c (HbA1c) value at screening of less than 6.5 percent (%). * Have a body mass index between 25 and 45 Kilogram per Square Meter (kg/m²). * Have had a stable body weight that has changed by less than 5% during the 3 months prior to screening. * Are individuals assigned male at birth (AMAB) or assigned female at birth (AFAB). Individuals of childbearing potential (IOCBP) and individuals not of childbearing potential (INOCBP) may participate in this study. Exclusion Criteria: * Have type 1 or type 2 diabetes mellitus, a history of ketoacidosis, or of hyperosmolar state or coma. Note: Participants with a history of gestational diabetes are eligible to participate in this study. * Have acute or chronic pancreatitis or a history of acute idiopathic pancreatitis. * Have a known clinically significant gastric emptying abnormality or chronically take drugs that directly affect gastrointestinal (GI) motility to a significant extent. * Have a prior or planned surgical treatment for obesity. Exceptions: The following are allowed if they occurred more than 1 year before screening: * liposuction * cryolipolysis, or * abdominoplasty. * Are unwilling to comply with the lifestyle and dietary restrictions required for this study. * Are individuals AFAB who are lactating. * Are individuals AFAB who are pregnant or intend to become pregnant or to breastfeed during the study, or individuals AMAB who intend to conceive a pregnancy during the study.

Study locations

2 registered sites.

Germany · Sweden. Showing up to 24 locations stored in the fast local snapshot.

Profil Institut für Stoffwechselforschung

Neuss, Germany

CTC GoCo

Mölndal, Sweden

Publications

Results and literature.

No PMID-linked publications were present in this registry snapshot.

Primary links

Continue at the source.

Related trials

More studies on Eloralintide.

Related PeptideStat pages

Put the record in context.

Research pages describe evidence. Vendor pages, where available, describe independently tracked research-product listings and are not clinical recommendations.