Current partner codePEPTIDESDE
Evidence dashboardStudies since 2010Updated Jul 31, 2026

PlecanatideClinical Trials.

A source-linked view of every Plecanatide study in the current snapshot—status, phase, enrollment, results, publications, locations and changes over time.

Total trials
15
Recruiting
0
Completed
14
Terminated
0
Results posted
11
Average enrollment
879
Countries
3
Highest phase
Phase 3

Developer / research origin

Synergy Pharmaceuticals

Evidence summary

Activity is not efficacy.

Plecanatide appears in 15 indexed studies: 0 recruiting, 14 completed and 11 with registry results posted. The highest registered development stage in this snapshot is Phase 3. These counts measure registry activity; they do not establish that Plecanatide is safe or effective.

Review the design, endpoints, population, protocol changes, statistical analysis and publications before drawing conclusions.

Development history

Trial timeline.

Evidence timeline

20102026

Velocity

Plecanatide studies by start year

Study start year · indexed snapshot

2211020102010: 1 trials2011: 1 trials2012: 1 trials20132013: 2 trials2014: 2 trials2015: 1 trials20162016: 1 trials2017: 1 trials2018: 2 trials20192019: 0 trials2020: 0 trials2021: 0 trials20222022: 2 trials2023: 0 trials2024: 0 trials20252025: 0 trials20262026: 1 trials

Development

Trials by phase

Early Phase 10
Phase 11
Phase 26
Phase 38
Phase 40

Current studies

Recruiting or active

Completed studies

Finished records

Stopped studies

Withdrawn or terminated

Showing 6 of 14 studies
No studies in this snapshot.

Full study index

Search Plecanatide trials.

Add status, phase, condition, country, result and publication filters inside this molecule’s indexed study set.

15 matching studies

End of 15 results

Latest publications

Follow the paper trail.

PMID 30277094Barish CF, Crozier RA, Griffin PH. Long-term treatment with plecanatide was safe and tolerable in patients with irritable bowel syndrome with constipation. Curr Med Res Opin. 2019 Jan;35(1):81-85. doi: 10.1080/03007995.2018.1527303. Epub 2018 Oct 9.Linked from NCT02706483PMID 37332239Cash BD, Sharma A, Walker A, Laitman AP, Chang L. Plecanatide for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation: Post hoc analyses of placebo-controlled trials in adults with severe constipation. Neurogastroenterol Motil. 2023 Sep;35(9):e14632. doi: 10.1111/nmo.14632. Epub 2023 Jun 18.Linked from NCT01982240PMID 37162147Rao SSC, Laitman AP, Miner PB Jr. Influence of Demographic Factors on Clinical Outcomes in Adults With Chronic Idiopathic Constipation Treated With Plecanatide. Clin Transl Gastroenterol. 2023 Jul 1;14(7):e00598. doi: 10.14309/ctg.0000000000000598.Linked from NCT01982240PMID 35086735Moshiree B, Schoenfeld P, Franklin H, Rezaie A. The Effect of Acid Suppression Therapy on the Safety and Efficacy of Plecanatide: Analysis of Randomized Phase III Trials. Clin Ther. 2022 Jan;44(1):98-110.e1. doi: 10.1016/j.clinthera.2021.11.009. Epub 2022 Jan 25.Linked from NCT01982240PMID 32660770Menees SB, Franklin H, Chey WD. Evaluation of Plecanatide for the Treatment of Chronic Idiopathic Constipation and Irritable Bowel Syndrome With Constipation in Patients 65 Years or Older. Clin Ther. 2020 Jul;42(7):1406-1414.e4. doi: 10.1016/j.clinthera.2020.05.012. Epub 2020 Jul 10.Linked from NCT01982240PMID 28169285Miner PB Jr, Koltun WD, Wiener GJ, De La Portilla M, Prieto B, Shailubhai K, Layton MB, Barrow L, Magnus L, Griffin PH. A Randomized Phase III Clinical Trial of Plecanatide, a Uroguanylin Analog, in Patients With Chronic Idiopathic Constipation. Am J Gastroenterol. 2017 Apr;112(4):613-621. doi: 10.1038/ajg.2016.611. Epub 2017 Feb 7.Linked from NCT01982240PMID 29343131Barish CF, Griffin P. Safety and tolerability of plecanatide in patients with chronic idiopathic constipation: long-term evidence from an open-label study. Curr Med Res Opin. 2018 Apr;34(4):751-755. doi: 10.1080/03007995.2018.1430024. Epub 2018 Feb 2.Linked from NCT01919697PMID 41214272Brenner DM, Shin AS, Laitman AP, Deutsch JK, Kunkel DC. The Effectiveness of Plecanatide for Treating Constipation and Bloating in Patients Aged 18 to 40 Years With Irritable Bowel Syndrome: Utilization of a New Composite Trisymptom Endpoint. J Gastroenterol Hepatol. 2025 Dec;40(12):2890-2897. doi: 10.1111/jgh.70119. Epub 2025 Nov 10.Linked from NCT02387359

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Commercial research listings, where present, are kept separate from clinical evidence and are not treatment recommendations.