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Research onlyHealing & recoverySubcutaneousEvidence 2/5

TB-500

Also known as: Thymosin Beta-4 fragment

Synthetic fragment of thymosin β4 studied in animal models for cell migration, angiogenesis and tissue repair. No approved human indication.

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This page is a structured profile. Narrative evidence, dosing context and FAQs live on the research guide — not duplicated here as a second full article.

Illustrative subcutaneous database profile for TB-500
Illustrative profileSubcutaneous
Database profileResearch only
TB-500Healing & recovery
Drug class
Thymosin β4 derivative
Primary targets
G-actin
Dose reference
No human dosing established
Half-life
Not well characterized
Developer / origin
RegeneRx (related TB4 program)
Reference year
1981
Evidence score
2/5 - Indirect preclinical evidence
Evidence 2/5

Indirect preclinical evidence

TB-500 claims mostly rely on thymosin beta-4 repair biology and preclinical data rather than direct human TB-500 outcome trials.

Mostly animal, ex vivo, cell, or indirect evidence.

Evidence basis

  • Thymosin beta-4 repair biology
  • Preclinical repair literature
  • Weak direct human TB-500 evidence

How to read this entry

Dose references and half-life values are pulled from trial protocols, labels, reviews, or published summaries where available. They are context for research and comparison, not a personal dosing recommendation.

Status matters: approved drugs have regulated indications; investigational compounds are still being studied; research-only peptides do not have established human dosing, safety, or efficacy for consumer use.

TB-500 guides

Read the matching guide or adjacent research pages for more context.

BPC-157 vs TB-500: Which Recovery Peptide Has Better Evidence?BPC-157 and TB-500 are both marketed for recovery, but their evidence is mostly preclinical. Side by side, BPC-157 has more direct injury-model papers; neither is proven in humans.Did the FDA Approve BPC-157? What the July 2026 Vote Actually MeansHeadlines said FDA approved BPC-157. The real story is a non-binding PCAC vote on the 503A compounding list, not NDA approval, not a sports-medicine label, not proof it works in humans.Banned Peptides in Sport: WADA Rules for BPC-157, CJC-1295 and SecretagoguesA peptide can be popular in recovery forums and still be prohibited in sport. WADA risk depends on approval status, mechanism, growth-factor effects and the current Prohibited List.FDA Peptide Compounding Rules: Category 2, Safety Risks and Research PeptidesCategory 2 warnings, 503A bulks-list rules and the July 2026 PCAC recommendations do not turn BPC-157 or TB-500 into FDA-approved drugs. Here is the accurate framing.

TB-500 calculator shortcuts

Open peptide calculators with editable TB-500 example values already filled in.

TB-500 reconstitution calculatorPrefills a 5 mg vial, 2 mL BAC water and editable dose fields.Open prefilled toolTB-500 unit converterPrefills 2 mg with a 5 mg vial example.Open prefilled tool

Peptide calculators

Use calculators for concentration, unit conversion and repeated-dose accumulation math.

Peptide reconstitution calculatorCalculate concentration, draw volume and syringe units from vial strength and BAC water.Open toolPeptide accumulation calculatorModel repeated dosing schedules with half-life, interval, peak and trough estimates.Open toolPeptide unit converterConvert mg, mcg, optional IU and syringe units from one reconstituted vial setup.Open toolPeptide chemistry calculatorAnalyze sequence length, molecular weight, composition, charge, hydropathy and notation.Open tool

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Thymosin beta-4 sequesters monomeric G-actin to regulate the actin cytoskeleton, enabling cell migration, angiogenesis and tissue repair, with an anti-fibrotic Ac-SDKP fragment.

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VIP activates VPAC1 and VPAC2 receptors, raising intracellular cyclic AMP to drive vasodilation, smooth-muscle relaxation and immune modulation.

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Category hub

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Healing Peptides

Compare healing peptides such as BPC-157 and TB-500 by evidence quality, mechanism, research status and practical limitations.

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