PEPTIDESTAT
Research onlyHealing & recoverySubcutaneousEvidence 3/5

Thymosin Beta-4

Also known as: TB4, Tβ4

Thymosin beta-4 sequesters monomeric G-actin to regulate the actin cytoskeleton, enabling cell migration, angiogenesis and tissue repair, with an anti-fibrotic Ac-SDKP fragment.

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Thymosin Beta-4
Drug class
Endogenous actin-sequestering peptide (beta-thymosin family)
Primary targets
G-actin
Dose reference
No established therapeutic dose; phase 1 IV studies used 42-1260 mg
Half-life
Short, dose-dependent ~1-2 hours (IV)
Developer / origin
RegeneRx
Reference year
1981
Evidence score
3/5 - Mechanistically strong, clinically narrow
Evidence 3/5

Mechanistically strong, clinically narrow

Thymosin beta-4 is a genuine endogenous actin-sequestering peptide with angiogenic and anti-fibrotic biology. Human evidence is strongest for topical/ocular use; systemic injectable use for recovery is unproven.

Limited human pharmacology or small clinical evidence.

Evidence basis

  • Phase 3 ophthalmic program (RGN-259) in dry eye and neurotrophic keratopathy
  • Preclinical dermal wound and cardiac repair data
  • Phase 1 IV tolerability to 1260 mg with no dose-limiting toxicity
  • No FDA-approved drug; consumer products often supply the TB-500 fragment

How to read this entry

Dose references and half-life values are pulled from trial protocols, labels, reviews, or published summaries where available. They are context for research and comparison, not a personal dosing recommendation.

Status matters: approved drugs have regulated indications; investigational compounds are still being studied; research-only peptides do not have established human dosing, safety, or efficacy for consumer use.

Thymosin Beta-4 guides

Read the matching guide or adjacent research pages for more context.

Thymosin Beta-4 Peptide: Actin Biology and Healing EvidenceThymosin beta-4 is a real endogenous actin-binding peptide with genuine wound, corneal and cardiac repair research, but systemic injectable use remains research-only.TB-500 Peptide: Thymosin Beta-4 Evidence and Safety LimitsTB-500 has a real thymosin beta-4 research trail behind it, but direct human recovery evidence for TB-500 protocols remains weak.BPC-157: Strong Animal Data, Almost No Human EvidenceBPC-157 is marketed hard for recovery and tissue repair. The animal data is genuinely interesting; the human data is almost entirely absent.Cortexin Peptide: Russian Cortical Polypeptide for Brain Injury and CognitionCortexin is a low-molecular-weight cortical polypeptide drug marketed in Russia, with mostly Russian-language evidence and no FDA or EMA approval.

Peptide calculators

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Compare with related peptides

Stay inside the same research category and compare mechanism, status and evidence quality.

BPC-157

Body Protection Compound-157

2/5
Healing & recoveryResearch only

Derived from human gastric juice. Animal models suggest effects on angiogenesis, tendon healing and GI repair; human clinical data is very limited.

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TB-500

Thymosin Beta-4 fragment

2/5
Healing & recoveryResearch only

Synthetic fragment of thymosin β4 studied in animal models for cell migration, angiogenesis and tissue repair. No approved human indication.

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2/5
Healing & recoveryInvestigational

VIP activates VPAC1 and VPAC2 receptors, raising intracellular cyclic AMP to drive vasodilation, smooth-muscle relaxation and immune modulation.

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Healing Peptides

Compare healing peptides such as BPC-157 and TB-500 by evidence quality, mechanism, research status and practical limitations.

Research & educational purposes only

The information on PeptideStat is for educational and research purposes only and is not medical advice. Many peptides discussed are research compounds not approved for human use. Always consult a qualified healthcare professional before making any health decisions. Articles may contain affiliate links — we may earn a commission at no extra cost to you.