PEPTIDESTAT
InvestigationalHealing & recoveryIntranasalEvidence 2/5

VIP (Vasoactive Intestinal Peptide)

Also known as: Aviptadil

VIP activates VPAC1 and VPAC2 receptors, raising intracellular cyclic AMP to drive vasodilation, smooth-muscle relaxation and immune modulation.

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VIP (Vasoactive Intestinal Peptide)
Drug class
Neuropeptide; VPAC1/VPAC2 receptor agonist
Primary targets
VPAC1, VPAC2
Dose reference
Route-dependent (investigational); e.g. inhaled aviptadil 50 mcg four times daily in studies
Half-life
~1 minute (plasma)
Developer / origin
Relief Therapeutics / NRx Pharmaceuticals (aviptadil)
Reference year
1970
Evidence score
2/5 - Weak / mixed
Evidence 2/5

Weak / mixed

VIP biology and VPAC receptor pharmacology are well characterized, but synthetic aviptadil failed its flagship COVID-19 respiratory trials and has only small or non-US-approved support elsewhere; popular intranasal use is unproven.

Mostly animal, ex vivo, cell, or indirect evidence.

Evidence basis

  • Large randomized TESICO trial of IV aviptadil for COVID-19 was negative
  • Only a small open-label sarcoidosis study showed a pulmonary signal
  • Aviptadil-phentolamine (Invicorp) approved for ED in some European countries, not US
  • Intranasal VIP for CIRS/mold illness has no published RCT

How to read this entry

Dose references and half-life values are pulled from trial protocols, labels, reviews, or published summaries where available. They are context for research and comparison, not a personal dosing recommendation.

Status matters: approved drugs have regulated indications; investigational compounds are still being studied; research-only peptides do not have established human dosing, safety, or efficacy for consumer use.

VIP (Vasoactive Intestinal Peptide) guides

Read the matching guide or adjacent research pages for more context.

VIP Peptide: Aviptadil, Receptors, Evidence and SafetyVIP is a short-lived signaling peptide whose synthetic form, aviptadil, has mixed clinical evidence and several unproven off-label uses.BPC-157: Strong Animal Data, Almost No Human EvidenceBPC-157 is marketed hard for recovery and tissue repair. The animal data is genuinely interesting; the human data is almost entirely absent.Cortexin Peptide: Russian Cortical Polypeptide for Brain Injury and CognitionCortexin is a low-molecular-weight cortical polypeptide drug marketed in Russia, with mostly Russian-language evidence and no FDA or EMA approval.Thymosin Beta-4 Peptide: Actin Biology and Healing EvidenceThymosin beta-4 is a real endogenous actin-binding peptide with genuine wound, corneal and cardiac repair research, but systemic injectable use remains research-only.

Peptide calculators

Use calculators for concentration, unit conversion and repeated-dose accumulation math.

Peptide reconstitution calculatorCalculate concentration, draw volume and syringe units from vial strength and BAC water.Open toolPeptide accumulation calculatorModel repeated dosing schedules with half-life, interval, peak and trough estimates.Open toolPeptide unit converterConvert mg, mcg, optional IU and syringe units from one reconstituted vial setup.Open toolPeptide chemistry calculatorAnalyze sequence length, molecular weight, composition, charge, hydropathy and notation.Open tool

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Research & educational purposes only

The information on PeptideStat is for educational and research purposes only and is not medical advice. Many peptides discussed are research compounds not approved for human use. Always consult a qualified healthcare professional before making any health decisions. Articles may contain affiliate links — we may earn a commission at no extra cost to you.