New Daily Persistent Headache Biomarkers Study

Calcitonin Gene-Related Peptide (CGRP) Levels in Blood

Time frame · At enrollment

Nerve Growth Factors (NGF) Levels in Blood

Time frame · At enrollment

Clinical characteristics of headache or chronic migraine Clinical characteristics clinical characteristics - need to list separately

Time frame · up to 30 days

Assessed through completion of self reported symptoms on 30 day calendar and review of medical records

Assessment of Light sensitivity

Time frame · At enrollment

The Photosensitivity Assessment Questionnaire that measures the extent to which a person is light sensitive. The questionnaire contains 16 "yes" or "no" questions.

Visual Aura Rating Scale (VARS) for migraine

Time frame · At enrollment

The VARS contains 5 "yes" or "no/not applicable" questions in which respondents are asked to indicate any visual disturbances when headache/migraine symptoms occur

Allodynia Symptom Checklist (ASC-12) Score

Time frame · At enrollment

The ASC 12 is a 12 item checklist that evaluates allodynia symptoms associated with headache attacks. Each situations are scored as "does not apply to me", "never", "rarely", "less than half", "half or more often". Total score ranged between 0-24 points.

Migraine Disability Assessment Score (MIDAS)

Time frame · At enrollment

The MIDAS contains 5 questions that identifies migraine disability in all areas of activity during the last 3 months. Total score ranges from 0-90 and is used to categorize patients in disability grades I to IV.

Pain Catastrophizing Scale (PCS)

Time frame · At enrollment

PCS consists of 13 items rated on a 5-point Likert scales from 0 (\[Not at all/Not Applicable) to 4 (All the time) points. The total score for the PCS is 52, with points more than 24 indicating a high level of catastrophizing

Pain Self-Efficacy Questionnaire

Time frame · At enrollment

This consists of 10 items rated on a 10-point Likert scales from 0 ( not at all confident) to 6(completely confident). It will be used to assess the participants' confidence in their ability to perform specific tasks or their confidence in performing more generalized constructs such as coping with chronic non-malignant pain.

Patient Health Questionnaire-9 (PHQ-9)

Time frame · At enrollment

PHQ-9 is a self-administered depression scale, which scores each of the 9 DSM-IV (Diagnostic and Statistical Manual-IV) criteria as "0" (not at all) to "3" (nearly every day).PHQ-9 scores are summed, and scores of 5, 10, 15, and 20 represent mild, moderate, moderately severe, and severe depression, respectively

Generalized Anxiety Disorder 7-Item Scale (GAD-7)

Time frame · At enrollment

The GAD-7 is a validated instrument for the diagnosis and treatment response of anxiety disorder. It scores each of the 7 criteria 0" (not at all) to "3" (nearly every day)with a total score ranging from 0-21 . Scores of 5-9, 10-14, and 15-21 represent mild, moderate and severe generalized anxiety disorder, respectively.

Short Form 36 Health Survey (SF-36)

Time frame · At enrollment

The SF-36 will used to understand the health related quality-of -life of the participants over the past four weeks. The eight health concepts: limitations in physical activities because of health problems; limitations in social activities because of physical or emotional problems; limitations in usual role activities because of physical health problems; bodily pain; general mental health (psychological distress and well-being); limitations in usual role activities because of emotional problems; vitality (energy and fatigue); and general health perceptions will be searched. These outcomes will be grouped as physical component summary and mental component summary. The norm data is 0-100, the health related quality of life is increases as the scores are increased. The average score is 50.