PROCEDURE
Caridac surgery
Cardiac surgery
Status
Unknown
Phase
Not applicable
Enrollment
200
Locations
1
Results
Not posted
Publications
0
Study summary
Post-operative atrial fibrillation (POAF) is one of the common complicaiton following cardiac surgery, occurring in approximately 20%-40% patients. Although POAF is associated with longer hospital stays, most POAF is short lived and resolves in the 2-4 days afer cardiac surgery. However, a recent meta-analysis showed significant increases in 1,5, and 10 year mortality in POAF patients (odds ratio:1.60, 2.60, 1.51;95% confidence intervals: 1.52 to 1.68, 2.00 to 3.38, 1.43 to 1.60;P \<0.0001), the combined adjusted risk of death (16 studies, n =84,295) was also significantly increased in patients with POAF (hazard ratio: 1.25;95% confidence interval: 1.2-1.3;P \< 0.0001). These data highlight the need to understand better the underlying mechanism of POAF. A latest research in Nature reported levels of circulating calcitonin (CT), which is the main risk factor for atrial fibrillation (AF). Global disruption of CT receptor signalling in mice causes atrial fibrosis and increases susceptibility to AF. Here we will explore the relationship between CT and POAF.
Interventions
PROCEDURE
Cardiac surgery
Timeline
First posted
Aug 6, 2021
Study start
Jun 15, 2021
Primary completion
Jul 15, 2023
Study completion
Jul 15, 2024
Results posted
Not reported
Registry updated
Aug 17, 2021
Outcomes
POAF lasting longer than 30 seconds during the first week after cardiac surgery
Time frame · 2 years after cardiac surgery
The incidence of atrial fibrillation lasting longer than 30 seconds during the first week after cardiac surgery
The hospitalization days
Time frame · 2 years after cardiac surgery
The length of stay after the cardiac surgery
Ventricular rate of the atrial fibrillation
Time frame · 2 years after cardiac surgery
Ventricular rate of atrial fibrillation after the cardiac surgery
Levels of serum calcitonin
Time frame · 2 years after cardiac surgery
Levels of serum calcitonin of atrial fibrillation after the cardiac surgery
Levels of serum procalcitonin
Time frame · 2 years after cardiac surgery
Levels of serum procalcitonin of atrial fibrillation after the cardiac surgery
Levels of serum hsCRP
Time frame · 2 years after cardiac surgery
Levels of serum hsCRP of atrial fibrillation after the cardiac surgery
Levels of serum cytokines(IL-1β,IL-2R,IL-6,IL-8,IL-10,TNF-α)
Time frame · 2 years after cardiac surgery
Levels of serum cytokines(IL-1β,IL-2R,IL-6,IL-8,IL-10,TNF-α) of atrial fibrillation after the cardiac surgery
Atrial fibrillation burden after cardiac surgery
Time frame · lidan2014@tjh.tjmu.edu.cn
Time and length of atrial fibrillation after cardiac surgery
Eligibility
Inclusion Criteria: * 1\. Clinical diagnosis of no history of atrial fibrillation/flutter; * 2\. Heart rate ≥50 beats/min; * 3\. EF \> 40%; * 4\. No history of emergency cardiac surgery in our hospital; * 5\. Participate voluntarily and sign the informed consent, and can accept the follow-up of more than 2 years. Exclusion Criteria: * 1\. Atrial fibrillation/flutter; * 2\. Left atrial diameter \>5.5cm; * 3\. Previous cardiac surgery or emergency surgery (\<12h); * 4\. Sick sinus node syndrome; * 5\. Ventricular preexcitation or preexcitation syndrome; * 6\. Second degree or above atrioventricular block; * 7.Myocardial infarction occurred within 7 days; * 8\. Infection, sepsis, rheumatic or inflammatory diseases; * 9\. Abnormal liver and kidney function (three times higher than the upper limit of normal); * 10\. Uncontrolled hyperthyroidism, severe obstructive sleep apnea, and acute alcoholism; * 11\. Any ischemic events (stroke or TIA) that occurred 180 days before the participant signed the informed consent, or any known unresolved complications from previous stroke/TIA;Thrombosis; * 12\. Patients with other diseases requiring radiotherapy, chemotherapy and long-term hormone therapy; * 13\. Patients' life expectancy makes it unlikely that follow-up will be completed; * 14\. Participate in, or are expected to participate in, other clinical trials of any drugs, devices or biologics during the study period; * 15\. Patients with contraindications to dynamic electrocardiogram; * 16\. Patients who are unwilling or unable to fully comply with study procedures and follow-up.
Study locations
China. Showing up to 24 locations stored in the fast local snapshot.
Tongji Hospital
Wuhan, Hubei, China
Publications
No PMID-linked publications were present in this registry snapshot.
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