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NCT05235867·Not applicable·OBSERVATIONAL

Secretin in Refeeding

SecretinOtherRecruiting

Status

Recruiting

Phase

Not applicable

Enrollment

10

Locations

1

Results

Not posted

Publications

0

Study summary

What the protocol is testing.

Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Current data suggest that one hormone--named secretin--may control both urine output and how the body handles acid and base. This study will evaluate whether secretin levels are different in anorexic patients who urinate an excessive amount compared to those who urinate normal amounts. For this study, patients will have one extra blood draw before and after one meal during their hospitalization. The blood draw before the meal coincides with a standard of care blood draw. Also after the meal, subjects will be asked to provide one extra urine sample. Information from subject's medical records will also be used.

Interventions

Treatment arms and agents.

No intervention details reported.

Timeline

From registration to results.

  1. First posted

    Feb 11, 2022

  2. Study start

    Feb 1, 2022

  3. Primary completion

    Jun 30, 2027

  4. Study completion

    Dec 31, 2027

  5. Results posted

    Not reported

  6. Registry updated

    Feb 12, 2026

Outcomes

What the study measures.

Primary outcomes

Change in secretin

Time frame · 1 hour

Change in secretin value from pre- to post- meal

Secondary outcomes

Change in serum bicarbonate

Time frame · 1 hour

Change in bicarbonate value from pre- to post- meal

Eligibility

Who can take part.

Minimum age
13 Years
Maximum age
24 Years
Sex
ALL
Healthy volunteers
No

Inclusion Criteria: * Group 1: * male and female patients * age 13-24 years * diagnosis of restrictive-type anorexia nervosa * hospitalization for nutritional support * \>4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5) * Group 2: * male and female patients * age 13-24 years * diagnosis of restrictive-type anorexia nervosa * hospitalization for nutritional support * \<2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5) Exclusion Criteria: * 5150 hold * Anti-depressant, anti-psychotic, or anticonvulsant medications * Previous hospitalization within the past 6 months * Underlying metabolic disorder not related to anorexia nervosa (including chronic kidney disease, renal tubular disorders, and underlying endocrine disorders) * Pregnancy * NG or G-tube feeds after day 2 of hospitalization * \> 10% of nutritional needs from supplemental feeds

Study locations

1 registered sites.

United States. Showing up to 24 locations stored in the fast local snapshot.

University of California, Los Angeles (UCLA)

Los Angeles, California, United States

Publications

Results and literature.

No PMID-linked publications were present in this registry snapshot.

Primary links

Continue at the source.

ClinicalTrials.gov ↗Search PubMed ↗Search FDA ↗Search EMA ↗

Related trials

More studies on Secretin.

Related PeptideStat pages

Put the record in context.

Research pages describe evidence. Vendor pages, where available, describe independently tracked research-product listings and are not clinical recommendations.

TrialsSecretin trial dashboard →DatabaseSecretin database entry →ResearchSecretin research guide →