Real World Effectiveness of Eptinezumab in Participants With Migraine

Change From Baseline in Patient-informed Most Bothersome Symptom (PI-MBS) Score at Week 24

Time frame · Baseline, Week 24

Participants select the symptom that they find most impairs them at the time of reporting and rate the severity of that symptom on a 7-point scale (1 = very much improved; 2 = much improved; 3 = minimally improved; 4 = no change; 5 = minimally worse; 6 = much worse; 7 = very much worse) where a high score indicated worsening. Score ranges from 1 (Very Much Improved) to 7 (Very Much Worse). Lower scores indicate better health status. The MBS areas included: nausea, vomiting, sensitivity to light, sensitivity to sound, mental cloudiness, fatigue, pain with activity, mood changes, and other symptoms.

Number of "Good Days" From Baseline

Time frame · Up to Week 24

The participants report the number of "good days" and "bad days" they had in the previous week on a weekly basis using the good day/bad day scale.

Change From Baseline in Quality of Life (QOL) as Measured by the 5 Level Euro Quality of Life 5 Dimensional Questionnaire (EQ-5D-5L) Score at Week 24

Time frame · Baseline, Week 24

The EQ-5D-5L is a participant-reported assessment designed to measure the participant's well-being. It consists of 5 descriptive items (mobility, self-care, usual activities, pain/discomfort, and depression/anxiety) and a visual analog scale (VAS) of the overall health state. Each descriptive item is rated on a 5-point index ranging from 1 (no problems) to 5 (extreme problems). The VAS ranges from 0 (worst imaginable health state) to 100 (best imaginable health state).

Health Care Resources Utilization (HCRU): Number of Participants Who Used Health Services and Medications

Time frame · Up to Week 24

QOL as Measured by the 6 Item Headache Impact Test (HIT-6) Score

Time frame · Up to Week 24

The HIT-6 (version 1.0) is a Likert-type, self-reporting questionnaire designed to assess the impact of an occurring headache and its effect on the ability to function normally in daily life. The HIT-6 contains 6 questions, each item is rated from never to always with the following response scores: never = 6, rarely = 8, sometimes = 10, very often = 11, and always = 13. The total score for the HIT-6 is the sum of each response score ranging from 36 to 78. The life impact derived from the total score is described as follows: severe (≥60), substantial (56-59), some (50-55), little to none (≤49).

QOL as Measured by the Migraine Disability Assessment (MIDAS) Total Score

Time frame · Up to Week 24

The Midas score is a participant completed 5-item questionnaire about lost time and productivity (for work, school or family/social activities) in the past 3 months (number of days missed) where: 0-5=Little or No disability, 6-10=Mild disability, 11-20=Moderate disability or 21+ Severe disability.

Participant Satisfaction Score as Measured by the Treatment Satisfaction Questionnaire for Medication (TSQM)

Time frame · Week 24

The TSQM assesses four domains of participants' satisfaction with treatment, with scale ranges from 0 (extremely dissatisfied) to 100 (not at all dissatisfied) for each of the categories (Effectiveness, Side Effects, Convenience, and Overall Satisfaction).

Percentage of Participants That Switch From the Preventive Medication They Are Randomized to at Baseline to Another Preventive Medication

Time frame · Week 24